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| CAS No.: | 23356-96-9 |
|---|---|
| Name: | L-(+)-Prolinol |
| Article Data: | 99 |
| Molecular Structure: | |
|
|
|
| Formula: | C5H11NO |
| Molecular Weight: | 101.148 |
| Synonyms: | (2S)-2-Pyrrolidinylmethanol;(2S)-Pyrrolidin-2-ylmethanol;2-pyrrolidinemethanol, (2S)-;(S)-(+)-2-(Hydroxymethyl)pyrrolidine 99%;(S)-(+)-2-Pyrrolidinemethanol; |
| EINECS: | 245-605-2 |
| Density: | 0.978 g/cm3 |
| Melting Point: | 42-44℃ |
| Boiling Point: | 211 °C at 760 mmHg |
| Flash Point: | 86.1 °C |
| Solubility: | Fully miscible in water. Soluble in chloroform. |
| Appearance: | Colorless to light yellow liquid |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 26-36-37/39 |
| PSA: | 32.26000 |
| LogP: | 0.05950 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
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- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 147-85-3
L-proline
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| Stage #1: L-proline With lithium aluminium tetrahydride In tetrahydrofuran for 1.25h; Heating / reflux; Stage #2: With potassium hydroxide In tetrahydrofuran; water for 1.25h; Heating / reflux; | 100% |
| Stage #1: L-proline With lithium aluminium tetrahydride In tetrahydrofuran Inert atmosphere; Cooling with ice; Reflux; Stage #2: With potassium hydroxide In tetrahydrofuran at 20℃; Reflux; | 99% |
| With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 72.5h; Reflux; | 99% |
- 67-56-1
methanol
B
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride Heating; | A n/a B 96% |
- 67-56-1
methanol
B
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride Heating; | A n/a B 96% |
- 67-56-1
methanol
B
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride Heating; | A n/a B 96% |
- 67-56-1
methanol
B
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride Heating; | A n/a B 96% |
A
- 101692-94-8
(rac)-N-benzyl-N-methylalanine
B
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol Heating; | A n/a B 96% |
A
- 42492-62-6
2-(benzyl(methyl)amino)-3-methylbutanoic acid
B
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol Heating; | A n/a B 96% |
A
- 14464-19-8
(rac)-N-benzyl-N-methylphenylalanine
B
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol Heating; | A n/a B 96% |
B
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogenchloride In methanol Heating; | A n/a B 96% |
- 98-79-3
L-Pyroglutamic acid
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
| Conditions | Yield |
|---|---|
| With hydrogen; acetic acid In water at 100℃; under 52505.3 Torr; for 20h; Pressure; Temperature; Reagent/catalyst; Time; Autoclave; | 95% |
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Chemistry
Molecular Structure of L-(+)-Prolinol (CAS NO.23356-96-9):
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IUPAC Name: [(2S)-pyrrolidin-2-yl]methanol
Molecular Formula: C5H11NO
Molecular Weight: 101.15
H bond acceptors: 2
H bond donors: 2
Freely Rotating Bonds: 2
Polar Surface Area: 12.47 Å2
Index of Refraction: 1.454
Molar Refractivity: 28.02 cm3
Molar Volume: 103.3 cm3
Surface Tension: 36.5 dyne/cm
Density: 0.978 g/cm3
Flash Point: 86.1 °C
Enthalpy of Vaporization: 52.03 kJ/mol
Boiling Point: 211 °C at 760 mmHg
Vapour Pressure: 0.0423 mmHg at 25°C
Storage temp: 2-8°C
Sensitive: Air Sensitive
BRN: 79843
EINECS: 245-605-2
InChI
InChI=1/C5H11NO/c7-4-5-2-1-3-6-5/h5-7H,1-4H2
Smiles
N1[C@@H](CO)CCC1
Product Categories: Pharmaceutical Intermediates; Amines; blocks; Amino Alcohols; chiral;APIs; Proline [Pro, P]; Chemical Amines; Chiral Building Blocks; Glycidyl Compounds, etc. (Chiral); Synthetic Organic Chemistry; Amino alcohols; Amino Acids & Derivatives
Production
L-(+)-Prolinol (CAS NO.23356-96-9) is obtained by reduction of the amino acid proline using lithium aluminium hydride.Because proline is cheaply available in high optical purity, enantiomerically pure. L-Prolinol is also widely available.
Safety Profile
Hazard Symbols: 
Xi
Risk Codes: R36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Description: S26;S37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
WGK Germany: 3
F: 3-10-23
Hazard Note: Irritant/Air Sensitive
Specification
L-(+)-Prolinol , with CAS number of 23356-96-9, can be called (S)-(+)-2-Pyrrolidinemethanol ; (S)-(+)-2-(Hydroxymethyl)pyrrolidine 99% ; 2-pyrrolidinemethanol, (2S)- ; (2S)-Pyrrolidin-2-ylmethanol ; (2S)-2-Pyrrolidinylmethanol . It is a colorless to light yellow liquid. L-(+)-Prolinol (CAS NO.23356-96-9) is used in broad variety of chemical reactions as chiral ligand, chiral catalyst or chiral auxiliary reagent in the Hajos-Parrish-Eder-Sauer-Wiechert reaction, the Baylis-Hillman reaction, Noyori type reaction and the Michael reaction.