Detail of "2353-33-5"

CAS Number:
2353-33-5
Name:
5-Aza-2'-deoxycytidine
Molecular Structure:
Formula:
C₈H₁₂N₄O₄
Molecular Weight:
228.24
Deleted CAS:
105597-46-4|123795-43-7
Synonyms:
s-Triazin-2(1H)-one,4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-(7CI,8CI);2-Desoxy-5-azacytidine;2'-Deoxy-5-azacytidine;5-Azadeoxycytidine;DAC;Dacogen;1,3,5-Triazin-2(1H)-one,4-amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-;b-Decitabine;
EINECS:
219-089-4
Density:
1.9 g/cm³
Melting Point:
~200 °C (dec.)
Boiling Point:
485.8 °C at 760 mmHg
Flash Point:
247.6 °C
Solubility:
acetic acid/water (1:1): 50 mg/mL
Appearance:
white crystalline powder
Hazard Symbols:
Xn,Xi
Risk Codes:
22-36/37/38
Safety:
26-36 Details

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Reference

In vitro cytotoxic and biochemical effects of 5-aza-2'-deoxycytidine: In vitro cytotoxic and biochemical effects of 5-aza-2'-deoxycytidine. Momparler, Richard L.; Goodman, Joel (Sch. Med., Univ. South. California, Los Angeles, Calif., USA). Cancer Res., 37(6), 1636-9 (English) 1977. CODEN: CNREA8. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The in vitro effect of 5-aza-2'-deoxycytidine (I) [2353-33-5] on cytotoxicity and macromol. synthesis in hamster fibrosarcoma cells was investigated. The in vitro concns. that produce 50% cell kill for I were about 1.0 and 0.01 .mu.g/mL for a 2- and 24-h exposure, resp. I inhibited the growth of the fibrosarcoma cells by 40% at 0.05 .mu.g/mL. Deoxycytidine, but not cytidine, was a potent antagonist of the cytotoxicity produced by I. At cytotoxic concns. I did not appear to inhibit DNA, RNA, or protein synthesis during a 1-h incubation as measured by the incorporation of radioactive thymidine, uridine, or leucine into acid-insol. material. At 10 .mu.g/mL, I stimulated the incorporation of radioactive thymidine into DNA by more than 50%. These results indicate that I is a very potent cytotoxic agent to tumor cells in vitro at concns. that do not inhibit macromol. syntesis.

In vitro transformation of primary rat tracheal epithelial cells by 5-azacytidine: In vitro transformation of primary rat tracheal epithelial cells by 5-azacytidine. Walker, Cheryl; Nettesheim, Paul (Lab. Pulm. Pathobiol., Natl. Inst. Environ. Health Sci., Research Triangle Park, NC 27709, USA). Cancer Res., 46(12, Pt. 1), 6433-7 (English) 1986. CODEN: CNREA8. ISSN: 0008-5472. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The ability of the hypomethylating agent 5-azacytidine (I) [320-67-2] to transform normal primary rat tracheal epithelial cells was detd. A single 24-h exposure to 5-azacytidine resulted in the transformation of rat tracheal epithelial cells at concns. ranging from 1 to 4 mM. Doses of 5-azacytidine that produced these enhanced growth transformants were nonmutagenic as measured by the induction of 6-thioguanine or ouabain resistance. In addn., the hypomethylating agent 5-azadeoxycytidine [2353-33-5] also transformed primary rat tracheal epithelial cells, whereas 6-azacytidine [3131-60-0], a cytosine analog which does not induce DNA hypomethylation, did not. Enhanced growth transformants resulting from 5-azacytidine exposure continued to progress in the absence of further treatment to give rise to variants with indefinite growth capacity which ultimately became neoplastic. Thus, hypomethylating agents can transform normal cells and changes in DNA methylation may occur during the initial stages of neoplastic transformation.

Detail of "2353-33-5"

5-Aza-2'-deoxycytidine

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CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

CAS No.2353-33-5 5-Aza-2'-deoxycytidine

Reference