CAS No.23541-50-6,Daunorubicin hydrochloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	23541-50-6
Name:	Daunorubicin hydrochloride
Article Data:	6

Formula:	C₂₇H₂₉NO₁₀^.HCl
Molecular Weight:	563.989
Synonyms:	5,12-Naphthacenedione,8-acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-,hydrochloride, (8S,10S)- (9CI);Cerubidine;Daunoblastin;Daunomycin chlorohydrate;NDC0082-4155;Ondena;RP 13057 hydrochloride;Rubidomycin hydrochloride;
EINECS:	245-723-4
Density:	1.554 g/cm³
Melting Point:	190°C (dec)
Boiling Point:	770 °C at 760 mmHg
Flash Point:	419.5 °C
Appearance:	dark red crystals
Hazard Symbols:	Xn,Xi
Risk Codes:	22-40-42/43-36/37/38-20/21/22
Safety:	22-36/37-45-37/39-36-26
Transport Information:	UN 2811 6.1/PG 3
PSA:	185.84000
LogP:	2.53120

Synthetic route

: 36508-71-1
Benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride

A: 23541-50-6
daunomycin hydrochloride

B: 613-94-5
benzoic acid hydrazide

Conditions

Conditions	Yield
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer;

: 110925-43-4
Nicotinic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride

A: 553-53-7
Nicotinic acid hydrazide

B: 23541-50-6
daunomycin hydrochloride

Conditions

Conditions	Yield
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, pH 6.80, pH 7.35, 0.01 M phosphate buffer;

: 110925-39-8
Isonicotinic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride

A: 54-85-3
isoniazid

B: 23541-50-6
daunomycin hydrochloride

Conditions

Conditions	Yield
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, pH 6.80, pH 7.35, 0.01 M phosphate buffer;

: 110925-32-1
4-Amino-benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride

A: 23541-50-6
daunomycin hydrochloride

B: 5351-17-7
4-aminobenzohydrazide

Conditions

Conditions	Yield
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer;

: 66996-57-4
4-Hydroxy-benzoic acid [1-[(2S,4S)-4-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene]-hydrazide; hydrochloride

A: 23541-50-6
daunomycin hydrochloride

B: 5351-23-5
4-hydroxybenzoic acid hydrazide

Conditions

Conditions	Yield
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer;

: 110925-36-5
3-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride

A: 23541-50-6
daunomycin hydrochloride

B: 110925-44-5
ethyl m-hydrazinecarbonyl benzoate

Conditions

Conditions	Yield
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer;

: 110925-37-6
4-[1-[(2S,4S)-4-((2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyl-tetrahydro-pyran-2-yloxy)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-naphthacen-2-yl]-eth-(E)-ylidene-hydrazinocarbonyl]-benzoic acid ethyl ester; hydrochloride

A: 19827-16-8
4-hydrazinocarbonyl-benzoic acid ethyl ester

B: 23541-50-6
daunomycin hydrochloride

Conditions

Conditions	Yield
With water at 37℃; Rate constant; also half-conversion period, pH 5.58, 0.01 M phosphate buffer;

: 193743-47-4
daunoform

: 23541-50-6
daunomycin hydrochloride

Conditions

Conditions	Yield
Stage #1: daunoform In dimethylsulfoxide-d6; water-d2 for 24h; Stage #2: With hydrogenchloride In dimethylsulfoxide-d6; water-d2

: 23541-50-6
daunomycin hydrochloride

: 407-25-0
trifluoroacetic anhydride

: 219921-59-2
3'-N,4'-O-di-trifluoroacetyldaunomycin

Conditions

Conditions	Yield
In dichloromethane at -2 - 2℃; for 1h; Inert atmosphere;	100%
In dichloromethane at -2 - 2℃; for 1h; Inert atmosphere;	100%
In dichloromethane at 0℃; for 1.5h;

: Pyr-His-Trp-Tyr-D-Lys(NH2-O-CH2-CO-Gly-Phe-Leu-Gly)Trp-Tyr-Pro-Gly-NH2

: 23541-50-6
daunomycin hydrochloride

: [D-Lys6(Dau=Aoa-GFLG)]GnRH-II

Conditions

Conditions	Yield
In aq. acetate buffer at 20℃; for 24h; pH=5.2;	100%

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Chemistry

MF: C₂₇H₃₀ClNO₁₀
MW: 563.98
EINECS: 245-723-4
mp： 190°C (dec)
storage temp： 20°C
form: solid
Merck: 13,2852
Synonyms:WP900 HYDROCHLORIDE;daunoblastin;daunoblastina; daunomycinchlorohydrate; ndc00824155;ondena;rp13057hydrochloride; rubidomycinhydrochloride
The structure of Daunorubicin hydrochloride(23541-50-6) is:

Uses

Daunorubicin hydrochloride(23541-50-6) ia used as anthracycline antibiotic related to the rhodomycins. Antineoplastic.

Toxicity Data With Reference

1.	mmo-sat 83 ng/plate	CNREA8 Cancer Research. 38 (1978),2148.
2.	mmo-asn 250 mg/L	MUREAV Mutation Research. 97 (1982),293.
3.	orl-rat LD50:290 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),437.
4.	ipr-rat LD50:14,300 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),437.
5.	scu-rat LD50:33,200 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),437.
6.	ivn-rat LD50:14,300 µg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),437.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Hazard Codes: Xn,Xi
Risk Statements: 22-40-42/43-36/37/38-20/21/22
Safety Statements: 22-36/37-45-37/39-36-26
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: HB7878000
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Mutation data reported. An antineoplastic agent. When heated to decomposition it emits very toxic fumes of NO_x and HCl.

Specification

Daunorubicin hydrochloride(23541-50-6) may emit toxic oxides of nitrogen when heated.