Detail of "236098-40-1"

Reference

Nociceptin/orphanin FQ prevents the antinociceptive action of paracetamol on the rat hot plate test

Nociceptin/orphanin FQ prevents the antinociceptive action of paracetamol on the rat hot plate test. Sandrini, Maurizio; Vitale, Giovanni; Pini, Luigi Alberto; Lopetuso, Giuseppe; Romualdi, Patrizia; Candeletti, Sanzio (Department of Biomedical Sciences, Section of Pharmacology, Italy). European Journal of Pharmacology, 507(1-3), 43-48 (English) 2005 Elsevier B.V. CODEN: EJPHAZ.Some commonly used reagents like 170713-75-4 and 236098-40-1 are used in this experiment. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 1 Nociceptin/orphanin FQ (N/OFQ) is involved in many behavioral patterns; in particular, it exerts a modulating effect on nociception. Like other proposed antiopiates, nociceptin/orphanin FQ has been shown to have analgesic, hyperalgesic as well as antianalgesic properties. Among the various effects proposed on nociceptive sensitivity at supraspinal level, the antagonistic activity toward morphine analgesia seems to be of interest. Therefore, the authors decided to investigate whether nociceptin/orphanin FQ and [Arg14, Lys15] nociceptin/orphanin FQ (R-K, a nociceptin analog) can have the same effect on the analgesia produced by nonopioid analgesics. In this study, the authors examd. the antianalgesic effect of nociceptin/orphanin FQ and its analog R-K on paracetamol-induced analgesia and evaluated by the hot plate test in rats. Nociceptin/orphanin FQ was intracerebroventricularly administered, and, after 5 min, a dose of 400 mg/kg paracetamol was injected i.p., 30 min before the hot plate test. Nociceptin/orphanin FQ and R-K showed a dose-dependent antagonism on the antinociceptive effect of paracetamol, and the activity of both drugs was significantly reduced by the antagonist [Nphe1] Arg14, Lys15-N/OFQ-NH2 (UFP-101). These data indicate that nociceptin/orphanin FQ and R-K have an antianalgesic effect on the analgesia produced by a nonopioid analgesic drug, like paracetamol, that seems to develop within the brain. .