CAS No.2364-75-2,2-Ethyl-3-hydroxy-6-methylpyridine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	2364-75-2
Name:	2-Ethyl-3-hydroxy-6-methylpyridine
Article Data:	5

Formula:	C₈H₁₁NO
Molecular Weight:	137.181
Synonyms:	2-Ethyl-6-methyl-3-hydroxypyridine;2-Ethyl-6-methyl-3-pyridinol;6-Methyl-2-ethyl-3-hydroxypyridine;Emoxipin;Emoxipine;Emoxypine;Epigid;Epygid;3-Pyridinol,2-ethyl-6-methyl-;
EINECS:	502-841-3
Density:	1.053 g/cm³
Melting Point:	136-138 °C
Boiling Point:	280.6 °C at 760 mmHg
Flash Point:	123.5 °C
Hazard Symbols:	Xi
PSA:	33.12000
LogP:	1.65800

Synthetic route

: 10599-69-6
5-methyl-2-propionylfuran

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
With ammonia; toluene-4-sulfonic acid at 170℃; under 10501.1 Torr; for 5h; Temperature; Pressure; Autoclave;	96.2%
With ethanol; ammonia at 170℃;
Multi-step reaction with 3 steps 1: NH2OH*HCl, NaOH / ethanol; H2O / 0.33 h / Heating 2: Raney Ni alloy, 2 N aq. NaOH / ethanol / 1 h / Ambient temperature 3: 1.) oxygen, tetraphenylporphine, 2.) triphenylphosphine / 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min View Scheme

: 1344663-48-4
2-ethyl-6-methylpyridin-3-amine

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite In water at 0℃; Reflux;	90%

: 64271-00-7
1-(5-methyl-2-furyl)propylamine

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
With oxygen; 5,15,10,20-tetraphenylporphyrin; triphenylphosphine 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min; Yield given. Multistep reaction;

: 534-22-5
2-methylfuran

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: FeCl36H2O / 1,2-dichloro-ethane / 1 h / Heating 2: NH2OHHCl, NaOH / ethanol; H2O / 0.33 h / Heating 3: Raney Ni alloy, 2 N aq. NaOH / ethanol / 1 h / Ambient temperature 4: 1.) oxygen, tetraphenylporphine, 2.) triphenylphosphine / 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min View Scheme
Multi-step reaction with 2 steps 1: water containing phosphoric acid 2: ethanol; ammonia / 170 °C View Scheme

: 133712-93-3
1-(5-methyl-[2]furyl)-propan-1-one oxime

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Raney Ni alloy, 2 N aq. NaOH / ethanol / 1 h / Ambient temperature 2: 1.) oxygen, tetraphenylporphine, 2.) triphenylphosphine / 1.) CH2Cl2, -70 deg C, irradiation, 2 h, 2.) -70 deg C, 10 min View Scheme

: 21203-68-9
2-methyl-5-nitropyridine

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: carbamide peroxide; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C 2.1: tetrahydrofuran / -60 °C / Inert atmosphere 2.2: -60 - 20 °C / Inert atmosphere 3.1: iron; acetic acid / 5 h / 110 °C 4.1: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme

: 1344663-51-9
2-ethyl-6-methyl-3-nitropyridine-1-oxide

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: iron; acetic acid / 5 h / 110 °C 2: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme

: 36625-50-0
2-methyl-5-nitropyridine 1-oxide

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: tetrahydrofuran / -60 °C / Inert atmosphere 1.2: -60 - 20 °C / Inert atmosphere 2.1: iron; acetic acid / 5 h / 110 °C 3.1: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme

: 60891-70-5
1,3-diethyl 2-(5-nitropyridin-2-yl)propanedioate

: 2364-75-2
emoxypine

Conditions

Conditions	Yield
Multi-step reaction with 5 steps 1.1: sulfuric acid / Heating 2.1: carbamide peroxide; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C 3.1: tetrahydrofuran / -60 °C / Inert atmosphere 3.2: -60 - 20 °C / Inert atmosphere 4.1: iron; acetic acid / 5 h / 110 °C 5.1: sulfuric acid; sodium nitrite / water / 0 °C / Reflux View Scheme

: 2364-75-2
emoxypine

: 105-36-2
ethyl bromoacetate

: 125756-87-8
ethyl (2-ethyl-6-methylpyridyl)-3-oxyacetate

Conditions

Conditions	Yield
With potassium carbonate In acetone for 8h; Heating;	87%
With potassium carbonate 1.) acetone, reflux, 2 h, 2.) acetone, reflux, 8 h; Yield given. Multistep reaction;

Raw Materials

64271-00-7

36625-50-0

21203-68-9

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Chemistry

Molecular Structure of 2-Ethyl-3-hydroxy-6-methylpyridine (CAS NO.2364-75-2):

IUPAC Name: 2-Ethyl-6-methylpyridin-3-ol
Canonical SMILES: CCC1=C(C=CC(=N1)C)O
InChI: InChI=1S/C8H11NO/c1-3-7-8(10)5-4-6(2)9-7/h4-5,10H,3H2,1-2H3
InChIKey: JPGDYIGSCHWQCC-UHFFFAOYSA-N
Molecular Weight: 137.17904 [g/mol]
Molecular Formula: C₈H₁₁NO
XLogP3-AA: 1.7
H-Bond Donor: 1
H-Bond Acceptor: 2
Product Categories: pharmacetical; Pyridines
Index of Refraction: 1.536
Molar Refractivity: 40.59 cm³
Molar Volume: 130.1 cm³
Surface Tension: 41.6 dyne/cm
Density: 1.053 g/cm³
Flash Point: 123.5 °C
Enthalpy of Vaporization: 54.03 kJ/mol
Boiling Point: 280.6 °C at 760 mmHg
Vapour Pressure: 0.0022 mmHg at 25 °C
Melting Point: 136-138 °C
Classification Code: Anti-arrhythmia agents; Antioxidants; Cardiovascular Agents; Central Nervous System Agents; Drug / Therapeutic Agent; Hematologic Agents; Mutagens; Noxae; Platelet aggregation inhibitors; Protective Agents; Psychotropic drugs; Radiation-protective agents

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mammal (species unspecified)	LD50	unreported	620mg/kg (620mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Pharmaceutical Chemistry Journal Vol. 16, Pg. 259, 1982.
rat	LD50	unreported	900mg/kg (900mg/kg)		Toxicology and Applied Pharmacology. Vol. 85, Pg. 342, 1986.

Safety Profile

Safety Information of 2-Ethyl-3-hydroxy-6-methylpyridine (CAS NO.2364-75-2):
Hazard Codes: Xi
Hazard Note: Irritant

Specification

2-Ethyl-3-hydroxy-6-methylpyridine (CAS NO.2364-75-2), its Synonyms are 2-Ethyl-6-methyl-3-hydroxypyridine ; 2-Ethyl-6-methyl-3-oxypyridine ; 2-Ethyl-6-methyl-3-pyridinol ; Emoxipin ; Emoxipine ; Emoxypine ; Epigid ; Epygid ; 6-Methyl-2-ethyl-3-hydroxypyridine ; 3-Pyridinol, 2-ethyl-6-methyl- .