Detail of "2364-87-6"
- CAS Number:
- 2364-87-6
- Name:
Benzenesulfonamide,N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-
- Molecular Structure:
![Molecular Structure of 2364-87-6 (Benzenesulfonamide,N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-)](http://www.lookchem.com/300w/2010/0620/2364-87-6.jpg)
- Formula:
- C14H21 Cl N2 O3 S
- Molecular Weight:
- 332.88
- Synonyms:
- Benzenesulfonamide,N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methyl- (9CI); Benzenesulfonamide,N-[5-amino-1-(chloroacetyl)pentyl]-4-methyl-, (S)-; p-Toluenesulfonamide,N-[5-amino-1-(chloroacetyl)pentyl]-, L- (8CI);1-Chloro-3-tosylamido-7-amino-L-2-heptanone;L-1-Chloro-3-tosylamido-7-amino-2-heptanone; N-Tosyl-L-lysine chloromethyl ketone;N-Tosyl-L-lysyl chloromethyl ketone; Na-Tosyl-L-lysine chloromethyl ketone; Na-Tosyl-L-lysyl chloromethylketone; Na-p-Tosyl-L-lysine chloromethylketone; Na-p-Tosyl-L-lysylchloromethylketone; TLCK; Tosyl-L-lysine chloromethyl ketone; Tosyllysine chloromethylketone; Tosyllysyl chloromethyl ketone; a-N-(p-Tosyl)-L-lysyl chloromethyl ketone
- Density:
- 1.242g/cm3
- Melting Point:
- ~165 °C (dec.)
- Boiling Point:
- 509.8°Cat760mmHg
- Flash Point:
- 262.1°C
- Hazard Symbols:
- Risk Codes:
- 36/37/38
- Safety:
- Poison by intraperitoneal and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cl−, NOx, and SOx. See also KETONES. Details
Benzenesulfonamide,N-[(1S)-5-amino-1-(2-chloroacetyl)pentyl]-4-methyl-
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Reference
- Late preventive effects on carbon tetrachloride-induced necrosis of the inhibitor of proteases l-1-chloro-3-(tosylamido)-7-amino-2-heptanone (TLCK)
- Late preventive effects on carbon tetrachloride-induced necrosis of the inhibitor of proteases l-1-chloro-3-(tosylamido)-7-amino-2-heptanone (TLCK). De Ferreyra, E. C.; De Fenos, O. M.; Castro, J. A. (Cent. Invest. Toxicol., CONICET, Villa Martelli 1603, Argent.). Res. Commun. Chem. Pathol. Pharmacol., 46(2), 289-92 (English) 1984. CODEN: RCOCB8. ISSN: 0034-5164. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The administration to rats of the inhibitor of proteases l-1-chloro-3-(tosylamido)-7-amino-2-heptanone (TLCK) [2364-87-6] 6 or 10 h after CCL4 [56-23-5], significantly prevented liver necrosis induced by this hepatotoxin at 24 h. Degradative processes mediated by proteases and esterases might play a role in late stages of CCl4-induced liver cell injury.
- Tosyl-lysyl chloromethane alters glucocorticoid-receptor complex nuclear binding and physical properties
- Tosyl-lysyl chloromethane alters glucocorticoid-receptor complex nuclear binding and physical properties. Hubbard, John R.; Barrett, Alan J.; Kalimi, Mohammed (Med. Coll. Virginia, Virginia Commonwealth Univ., Richmond, VA 23298, USA). Endocrinology (Baltimore), 115(1), 65-72 (English) 1984. CODEN: ENDOAO. ISSN: 0013-7227. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effect of tosyl-lysyl chloromethane (I) [2364-87-6] (a serine proteinase [37259-58-8] inhibitor) on rat liver cytosolic glucocorticoid-receptor complex binding to isolated nuclei was investigated. I (1-2 mM) blocked nuclear binding when added before (but not after) thermal activation. Fifty percent inhibition occurred at ~1 mM I. Several and other serine proteinase inhibitors (tosyl-phenylalanyl chloromethane [402-71-1], phenylmethyl sulfonylfluoride [329-98-6], and diisopropyl fluorophosphate [55-91-4]) also depressed glucocorticoid-receptor complex nuclear binding. I, like molybdate, inhibited diln.-induced nuclear binding at low temp., altered the DEAE-cellulose [9013-34-7] binding characteristics of heat-treated glucocorticoid-receptor complexes, and caused glucocorticoid-receptor complexes to sediment at ~9-10 S (control complexes sedimented at 7-8 S) in low salt-sucrose d. gradients. I apparently modulates several properties of the glucocorticoid-receptor complex. I effects resemble those of molybdate, and a serine proteinase(s) could be involved in the mechanism of glucocorticoid-receptor complex activation into a nuclear-binding form.