Detail of "23669-79-6"

Reference

Synthesis and properties of phosphoramidite derivatives of modified nucleosides

Synthesis and properties of phosphoramidite derivatives of modified nucleosides. Tanaka, Toshiki; Tamatsukuri, Sigeru; Ikehara, Morio (Fac. Pharm.In this study， 98056-69-0 and 23669-79-6 are also used. Sci., Osaka Univ., Osaka 565, Japan). Chem. Pharm. Bull., 34(5), 2044-8 (English) 1986. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Protected N6-methyl-2'-deoxyadenosine (d-m6A), 2-amino-2'-deoxyadenosine (d-a2A), 2'-deoxyinosine (dI), 5-methyl-2'-deoxycytidine (d-m5C) and deoxyuridine (dU) were reacted with bis(diisopropylamino)methoxyphosphine in the presence of diisopropylammonium tetrazolide as the activating reagent to give the corresponding phosphoramidite derivs. in yields of 100, 65, 70, 78 and 65%, resp. The 31 P-NMR spectra of the products were measured. Using these compds., dinucleotides and trinucleotides were synthesized on a long-chain alkylamine controlled pore glass in quant. yields. The stability of 6-methyldeoxyadenosine and N,N-diisobutyryl-2-aminodeoxyadenosine to acid was examd. When protected di- and trinucleotides (m6A-T, a2A-T, T-m6A-T, T-a2A-T) bound to the support were treated with 3% trichloroacetic acid in CH2Cl2 depurination was negligible within 10 min (dinucleotide) or 60 min (trinucleotide). .

Hydrolysis of 2'-deoxy and 2'-fluoronucleoside-3'-phosphodiesters

Hydrolysis of 2'-deoxy and 2'-fluoronucleoside-3'-phosphodiesters. Kuo, L.Y.; Travers, K.; Chock, J. 23669-79-6 and 32001-55-1 are cas registry numbers. These chemicals are also mentioned in this article. (Department of Chemistry, Lewis and Clark College, Portland, OR 97219, USA). Nucleosides & Nucleotides, 15(11 & 12), 1741-1749 (English) 1996 Dekker. CODEN: NUNUD5. ISSN: 0732-8311. DOCUMENT TYPE: Journal CA Section: 33 (Carbohydrates) Two nucleoside analogs were synthesized to test the ribose conformational and electronic effects on phosphate hydrolysis at the 3' position. It was found that under alk. conditions, a 2'-fluoro-nucleoside (C3'-endo) I (R = F) resulted in a phosphate degrdn. that was ten times faster than the 2'-deoxynucleoside analog (C2'-endo) I (R = H). In addn. to kinetic differences, product distributions will be presented. .