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CAS No.: | 2378-95-2 |
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Name: | diethyl N-[4-(methylamino)benzoyl]-L-glutamate |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C17H24 N2 O5 |
Molecular Weight: | 336.388 |
Synonyms: | Glutamicacid, N-[p-(methylamino)benzoyl]-, diethyl ester (7CI); Glutamic acid,N-[p-(methylamino)benzoyl]-, diethyl ester, L- (8CI); L-Glutamic acid,N-[4-(methylamino)benzoyl]-, diethyl ester (9CI); DiethylN-(p-N-methylaminobenzoyl)glutamate; DiethylN-[4-(methylamino)benzoyl]-L-glutamate; N-(p-Methylaminobenzoyl)glutamic aciddiethyl ester |
Density: | 1.165g/cm3 |
Melting Point: | 88-89 °C |
Boiling Point: | 518.3°Cat760mmHg |
Flash Point: | 267.2°C |
PSA: | 93.73000 |
LogP: | 2.19700 |
diethyl N--L-glutamate
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
Conditions | Yield |
---|---|
With hydrogenchloride; hydrogen; palladium on activated charcoal In ethanol under 2482.3 Torr; for 3h; | 80% |
diethyl N-(p-aminobenzoyl)-L-glutamate
methyl iodide
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide for 26h; | 23% |
With N-ethyl-N,N-diisopropylamine In toluene at 90℃; for 18h; |
N-(4-iodo-benzoyl)L-glutamic acid
methylamine
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
Conditions | Yield |
---|---|
With sodium hydroxide; copper at 125℃; Behandeln des Dinatrium-Salzes der erhaltenen N-<4-Methylamino-benzoyl>-L-glutaminsaeure mit Chlorwasserstoff enthaltendem Aethanol; |
diethyl N-(p-aminobenzoyl)-L-glutamate
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 94 percent / sodium cyanoborohydride, bromocresol green, acetic acid / ethanol / 48 h / Ambient temperature 2: 91 percent / sodium cyanoborohydride, bromocresol green, aq. acetic acid / acetonitrile / 1 h / Ambient temperature 3: 80 percent / hydrogen, HCl / palladium on carbon / ethanol / 3 h / 2482.3 Torr View Scheme |
diethyl N--L-glutamate
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 91 percent / sodium cyanoborohydride, bromocresol green, aq. acetic acid / acetonitrile / 1 h / Ambient temperature 2: 80 percent / hydrogen, HCl / palladium on carbon / ethanol / 3 h / 2482.3 Torr View Scheme |
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: sodium nitrite; aqueous hydrochloric acid; aqueous potassium iodide solution / Diazotization 2: aq. NaOH solution; copper / 125 °C / Behandeln des Dinatrium-Salzes der erhaltenen N-<4-Methylamino-benzoyl>-L-glutaminsaeure mit Chlorwasserstoff enthaltendem Aethanol View Scheme |
diethyl N-(p-aminobenzoyl)-glutamate
potassium carbonate
methyl iodide
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
Conditions | Yield |
---|---|
In dichloromethane; ethyl acetate; N,N-dimethyl-formamide |
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
<6-(bromomethyl)-4-oxo-3(4H)-quinazolinyl>methyl 2,2-dimethylpropanoate
Diethyl N-(4-(N-((3,4-dihydro-4-oxo-3-((pivaloyl)oxy) methyl-6-quinazolinyl)methyl)methylamino)benzoyl)-L-glutamate
Conditions | Yield |
---|---|
With calcium carbonate In dimethyl amine at 50℃; for 24h; | 89.3% |
Iodoethanol
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
diethyl N-<4-benzoyl>-L-glutamate
Conditions | Yield |
---|---|
In various solvent(s) at 100℃; for 5h; | 86% |
diethyl <4-(N-methylamino)benzoyl>-L-glutamate
4-methoxy-6-oxo-7-chloro-5H-pyrimido<4,5-b><1,4>thiazine
diethyl N-methyl-N-<4-methoxy-6-oxo-5H-pyrimido<4,5-b><1,4>thiazin-7-yl>-p-aminobenzoyl-L-glutamate
Conditions | Yield |
---|---|
With triethylamine In 1,4-dioxane; water at 18 - 20℃; for 5h; | 81% |