Detail of "23795-03-1"

Reference

Preparation of sodium or potassium salts of probenecid and their application in injections together with b-lactam antibiotics

Preparation of sodium or potassium salts of probenecid and their application in injections together with b-lactam antibiotics. Wu, Xiaohui (Peop. Rep. China ).In this study，23795-03-1 is also used. Faming Zhuanli Shenqing Gongkai Shuomingshu CN 1631876 A 29 Jun 2005,31 pp. (Chinese). (People's Republic of China). CODEN: CNXXEV. CLASS: ICM: C07C311-16. ICS: A61P031-04; A61K045-06. APPLICATION: CN 2010-11287 1 Dec 2004. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 Sodium probenecid has mol. formula as C13H18NO4SNa (mole wt. of 307.34) and potassium probenecid of C13H18NO4K (mole wt. of 323.45). The process for prepg. probenecid by dissolving 0.9-102 NaOH or 0.17-173.44 KOH into 11.5-1308 purified water, adding 6.5-663 or 0.88-885.75 probenecid, heating to 60°C until probenecid reacted absolutely, regulating PH to 7.5-10, 0.45 mm film aseptic filtering, 0.22 mm secondary filtering to remove pyrogen, asepsis drying, while probenecid contg. 388.50% or 86.25%. Powder injections and freeze dried powder injections are made up by mixing 1 parts prepd. Na or K probenecid and 1-3 parts b-lactam antibiotics, asepsis subpackaging, then powder injections and freeze dried powder injections are i.v. injected or i.v. dripped with b-lactam antibiotics. Used b-lactam antibiotics comprises penicillin antibiotics (of penicillin G and ampicillin) and cephalosporin antibiotics (of cefazolin, cefuroxime, cefotaxime and cefoxitin). The title injection is used to extend the effective time of b-lactam antibiotics , increasing area under curve and increase drug bioavailability of b-lactam antibiotics. .