Detail of "23827-93-2"

Reference

Regional distribution of neuropeptide-metabolizing peptidases in the human brain

Regional distribution of neuropeptide-metabolizing peptidases in the human brain. Martins, Antonio R.; Lachat, J. J.; Del Bel, Elaine A. (Fac. Med., Univ. Sao Paulo, Ribeirao Preto 14.100, Brazil). Neuropept. Psychosom. Processes, Int. Conf. Integr. Neurohumoral Mech., Meeting Date 1982, 175-82. Edited by: Endroczi, Elember. Akad. Kiado: Budapest, Hung. (English) 1983. CODEN: 53HNAO. DOCUMENT TYPE: Conference CA Section: 2 (Mammalian Hormones) Section cross-reference(s): 13 Bradykinin [58-82-2]-degrading kininase [62887-91-6] activity was detd. in various human brain regions and the anterior and posterior pituitary (AP and PP, resp.). The highest activities were found in the nucleus caudatus, putamen, AP, and substantia nigra; these levels were ~2-fold those of the choroid plexus, PP, and hypothalamus. Kininase activity in human brains from consumptive patients were about 25% lower in the 4 highest enzyme-contg. regions. Bradykinin products: bradykinin 1-5 [23815-89-6], bradykinin 6-9 [96158-90-6], bradykinin 1-7 [23815-87-4], Phe-Arg [1238-09-1], Ser-Pro [23827-93-2], arginine [74-79-3], proline [147-85-3], glycine [56-40-6], phenylalanine [63-91-2], and serine [56-45-1] were also detd. in brain regions. These products indicate that enzymes with a specificity similar to endopeptidase A predominate in most of brain regions. The presence of a peptidase similar to endopeptidase B is also suggested for choroid plexus, globus pallidus, and PP. Other peptidases are also discussed.

Synthesis of bradykinin fragments and their effect on pentobarbital sleeping time in mouse

Synthesis of bradykinin fragments and their effect on pentobarbital sleeping time in mouse. Okada, Yoshio; Tuchiya, Yuko; Yagyu, Masami; Kozawa, Shunji; Kariya, Kimio (Fac. Pharm. Sci., Kobe Gakuin Univ., Kobe, Japan). Neuropharmacology, 16(5), 381-3 (English) 1977. CODEN: NEPHBW. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) The bradykinin [58-82-2] fragments, Gly-Phe-Ser-Pro [23827-99-8], Ser-Pro [23827-93-2], and Phe-Ser-Pro [21658-46-8] similarly prolonged the pentobarbital [57-33-0] sleeping time in mice when injected intracerebrally at doses of 0.5, 2.5, and 12.5 nmol. Bradykinin fragments lacking the Ser-Pro C-terminus did not prolong sleeping time, suggesting that this C-terminal structure was required for this activity.