Detail of "2389-45-9"

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CAS Number:
2389-45-9
Name:
N-Boc-N'-Cbz-L-lysine
Molecular Structure:
Formula:
C₁₉H₂₈N₂O₆
Molecular Weight:
380.43
Deleted CAS:
111155-42-1|84098-79-3
Synonyms:
Lysine, N(2),N(6)-dicarboxy-, N(6)-benzyl N(2)-tert-butyl ester, L-;Boc-Lys(Z)-OH;6-phenylmethoxycarbonylamino-2-(tert-butoxycarbonylamino)hexanoic acid;L-Lysine, N2-[ (1, 1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-;N2-[(1, 1-Dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl-L-lysine;(Carbobenzoxyl)(carbo-tert-butoxyl)lysine;Boc-L-Lys(Z)-OH;N-Boc-N-Cbz-L-lysine;Boc-Lys(Cbz)-OH;N-α-Boc-N-δ-Z-L-lysine;N2-[(1,1-dimethylethoxy)carbonyl]-N6-[(phenylmethoxy)carbonyl]-L-lysine;Boc-Lysine(Cbz)-OH;N6-[(1,1-dimethylethoxy)carbonyl]-N2-[(phenylmethoxy)carbonyl]-L-Lysine（Boc-Lys(Z)-OH）;
EINECS:
219-221-0
Density:
1.176 g/cm³
Boiling Point:
587 °C at 760 mmHg
Flash Point:
308.8 °C

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Reference

Design, synthesis and biological evaluation of cyclic angiotensin II analogs with 3,5 side-chain bridges role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists: Design, synthesis and biological evaluation of cyclic angiotensin II analogs with 3,5 side-chain bridges role of C-terminal aromatic residue and ring cluster for activity and implications in the drug design of AT1 non-peptide antagonists. Roumelioti, Panagiota; Polevaya, Ludmila; Zoumpoulakis, Panagiotis; Giatas, Nektarios; Mutule, Ilze; Keivish, Tatjana; Zoga, Anastasia; Vlahakos, Demetrios; Iliodromitis, E.; Kremastinos, Demetrios; Grdadolnik, Simona Golic; Mavromoustakos, Thomas; Matsoukas, John (Department of Chemistry, University of Patras, Patras 26500, Greece). Bioorganic & Medicinal Chemistry Letters, 12(18), 2627-2633 (English) 2002 Elsevier Science Ltd. CODEN: BMCLE8.In this experiment, several chemicals are used like 4474-91-3 2389-45-9 and 39608-31-6 are cas registry numbers. These chemicals are also mentioned in this article. ISSN: 0960-894X. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1, 22 The novel amide linked Angiotensin II (ANG II) cyclic analogs: g,e-cyclo(3, 5)-[Sar1-Glu3-Lys5-Ile8] ANG II (I) and g, e-cyclo(3, 5)-[Sar1-Glu3-Lys5-Phe8] ANG II (II) have been designed, synthesized and bioassayed in anesthetized rabbits in order to unravel structural ring cluster characteristics important for receptor activation. Analog I with Ile at position 8 was an inhibitor of Angiotensin II while analog II with Phe at position 8 was found to be an agonist. Similar results were reported for cyclic compds. that have reversed the linking between positions 3 and 5. The overall results show that positions 3 and 5 do not govern the biol. activity of the synthetic analogs. It also appears that the arom. ring cluster (Tyr-His-Phe) in agonist peptides is an essential stereo-electronic feature for Angiotensin II to exert its biol. activity. A non-peptide mimetic of ANG II, 1-[2'-[(N-benzyl)tetrazol-5-yl]biphenyl-4-yl]methyl-2-hydroxymethylbenzim idazole (BZI8) has been designed and synthesized. This mol. is more rigid and much less active than AT1 non-peptide mimetic losartan probably because it lacks to mimic the orientation of tetrazole and the pharmacophore segments of Bu chain and imidazole ring. ..

D-Valylleucyllysinanilide derivs: D-Valylleucyllysinanilide derivs. for quantitative anal. of plasminogen. (Daiichi Kagaku Yakuhin K. K., Japan). Jpn. Kokai Tokkyo Koho JP 58172354 A2 11 Oct 1983 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07C103-52; C12Q001-36. APPLICATION: JP 82-55405 5 Apr 1982. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 7 Title peptides I (R1 = R2 = alkyl) and their addn. salts were prepd. as agents for the quant. anal. of blood plasminogen. 2389-45-9 and 81638-72-4 which are cas registry numbers of substances are two of reagents here. Thus, Boc-Lys(Z)-OH (Boc = Me3CO2C, Z = PhCH2O2C) was amidated with aniline II by pivaloyl chloride in CHCl3 contg. pyridine and N-ethylpiperidine to give anilide III, which was used in the synthesis of I.2HCl (R1 = R2 = Pr) by stepwise couplings in soln. .

Detail of "2389-45-9"

N-Boc-N'-Cbz-L-lysine

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