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Detail of "2392-39-4"

  • MSDS Download
  • CAS Number:
  • 2392-39-4
  • Name:

  • Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt (1:2), (11b,16a)-

  • Superlist Name:
  • Dexamethasone 21-phosphate disodium salt
  • Molecular Structure:
  • Formula:
  • C22H30FO8P.2Na
  • Molecular Weight:
  • 516.45
  • Deleted CAS:
  • 55203-24-2
  • Synonyms:
  • Pregna-1,4-diene-3,20-dione,9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, disodium salt, (11b,16a)- (9CI);Dexagro;Dexamethasone 21-(disodium phosphate);Dexamethasone phosphate sodium salt;Dexamethazone sodium phosphate;Dezone;Disodium dexamethasone 21-phosphate;
  • EINECS:
  • 219-243-0
  • Melting Point:
  • 233-235 °C
  • Boiling Point:
  • 669.6 °C at 760 mmHg
  • Flash Point:
  • 358.7 °C
  • Solubility:
  • water: 50 mg/mL, clear, faintly yellow
  • Risk Codes:
  • 22-40-63
  • Safety:
  • 36/37/39 Details
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CAS No.2392-39-4 Dexamethasone 21-phosphate disodium salt

Name: Dexamethasone sodium phosphate CAS Number: 2392-39-4 Molecular Formula: C22H28FO8P?2Na EINECS: 219-243-0 Melting Point: 233-235 oC Boiling Point: 669.6 °C at 760 mmHg Flash Point: 358.7 °C Solubility: H2O: 50 mg/mL, clear, faintly yellow Appearance: White to off whi

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Reference

Effect of derivatization of the bioavailability of ophthalmic steroids
Effect of derivatization of the bioavailability of ophthalmic steroids. Development of an in vitro method of evaluation. Flint, Geoffrey R.; Morton, Dougal J. (Dep. Pharm., Univ. Zimbabwe, Harare, Zimbabwe). Arch. Ophthalmol. (Chicago), 102(12), 1808-9 (English) 1984. CODEN: AROPAW. ISSN: 0003-9950. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1 The uptake of dexamethasone (I) derivs. by bovine cornea (in vitro) depended on their lipophilicity. Among the 3 derivs., I acetate [1177-87-3] was absorbed the fastest, followed by the I alc. [50-02-2]; the Na phosphate deriv. [2392-39-4] showed the lowest uptake. Even though the acetate reached the peak level earlier, the total I uptake from the acetate and the alc. was similar. All derivs. achieved similar aq. humor concns. probably due to their differences in soly. Penetration of the cornea by the Na phosphate deriv. acts as a rate-limiting step for uptake by the aq. humor. The use of bovine eyes in vitro may be a convenient method for assessing ophthalmic bioavailability.
The effect of corticosteroid on adult human skin infected with herpes simplex virus in organ culture
The effect of corticosteroid on adult human skin infected with herpes simplex virus in organ culture. Nishino, Kenichi (Dep. Dermatol., Kyoto Prefect. Univ. Med., Kyoto, Japan). Kyoto-furitsu Ika Daigaku Zasshi, 93(12), 1089-98 (Japanese) 1984. CODEN: KFIZAO. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Human skin explants were maintained in organ culture using sponge matrix method. Cytopathic effect (CPE) was demonstrated in cultured epidermis infected with 1000 TCID50/mL of herpes simplex virus (HSV). The CPE appearance and virus multiplication in the explants treated with 2.5 mg dexamethasone Na phosphate [2392-39-4]/mL were compared with those in the untreated explants. The appearance of CPE was retarded in the dexamethasone-treated explants as compared with the untreated controls. Virus multiplication in FL cells treated with either 2.5 or 10 mg dexamethasone/mL was compared with that in the untreated FL cells. At 24 h after inoculation, the HSV yields in the dexamethasone-treated group were lower than that in the untreated control and the degree of depression appeared to be dose related. At 48 h after inoculation, there was no significant difference in the HSV yields between the dexamethasone-treated groups and the untreated control. Apparently, dexamethasone has no effect on HSV multiplication at 24 h and 48 h after the inoculation.
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