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Detail of "2393-92-2"

  • CAS Number:
  • 2393-92-2
  • Name:

  • Thiamphenicol glycinate

  • Molecular Structure:
  • Formula:
  • C14H18Cl2N2O6S
  • Molecular Weight:
  • 356.22
  • Synonyms:
  • Glycine,(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-[4-(methylsulfonyl)phenyl]propylester (9CI);Glycine,2-[(dichloroacetyl)amino]-3-hydroxy-3-[4-(methylsulfonyl)phenyl]propyl ester,[R-(R*,R*)]-;Glycine, a-ester with D-threo-(+)-2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]acetamide (8CI);Acetamide,2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]-,a-ester with glycine, D-threo-(+)-(8CI);Thiamphenicol glycine ester;Thiophenicolglycinate;Urfamicin;
  • Density:
  • 1.468 g/cm3
  • Boiling Point:
  • 672.5 °C at 760 mmHg
  • Flash Point:
  • 360.5 °C
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CAS No.2393-92-2 Thiamphenicol glycinate

CBNumber: CB3102589 Chemical Name: THIAMPHENICOL CAS No. 2393-92-2 Molecular Formula: C12H15Cl2NO5S Formula Weight: 356.22 MOL File: Mol file Property mp : 163-166 °C storage temp. : 0-6°C solubility : ethanol: 50 mg/mL, clear, colorless

Supplier:FUZHOU BORNI PHARMACEUTICAL SCI.& TECH.CO.,LTD. [ China (Mainland)]

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Reference

Drug interactions
Drug interactions. Effects of tolbutamide pretreatment on chloramphenicol and thiamphenicol metabolism. Fujisawa, Kiyoshi; Kurihara, Nobuo; Nishikawa, Hiroshi; Kimura, Atsuhito; Kojima, Michio; Ogura, Kazuo; Kameda, Haruo (Tokyo Jikeikai Univ., Tokyo, Japan). Nippon Rinsho Taisha Gakkai Kiroku, 12, 39-43 (Japanese) 1975. CODEN: NRTKDI. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Chloramphenicol succinate [3544-94-3] and thiamphenicol glycinate [2393-92-2] (75 mg/kg, i.m.) were metabolized and excreted more rapidly in rats pretreated with tolbutamide (I) [64-77-7] (250 mg/kg) than in animals not pretreated with I.
Chemical method for the determination of thiamphenicol
Chemical method for the determination of thiamphenicol. Shukrallah, I. (Natl. Organ. Drug Control Res., Cairo, Egypt). J. Drug Res., 14(1-2), 225-32 (English) 1983. CODEN: JDGRAX. ISSN: 0368-1866. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A chem. method for the quant. detn. of thiamphenicol (I) [15318-45-3] depended on the degrdn. of the dichloracetamido group to the amine compd., which was detd. in the nonaq. medium by titrn. The amine hydrochloride and the amine compds. were isolated and identified. The method could det. 20-250 mg I. The mean percentage found was 99.48%, and the procedure was applied to the detn. of I in tablets and I glycinate [2393-92-2] as the hydrochloride alone and in the injectable form. The title method has higher precision and is less time consuming than the procedure of the BP 1980.
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