Detail of "2398-81-4"

Reference

Preliminary study on the hypolipemic effects of nicotinic acid N-oxide alone and in association with clofibrate

Preliminary study on the hypolipemic effects of nicotinic acid N-oxide alone and in association with clofibrate. Palamara, G.; De Luca, G.; Materazzi, M. (Sez. Ric. Polifarma, Rome, Italy). Boll. Chim. Farm., 116(10), 596-600 (Italian) 1977. CODEN: BCFAAI. ISSN: 0006-6648. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In rats with Triton WR 1339-induced hyperlipemia, oral administration of nicotinic acid N-oxide (I) [2398-81-4] (75 mg/kg) plus clofibrate (II) [637-07-0] (300 mg/kg) had a greater hypocholestermic effect than did administration of either compd. alone. The ability of each compd. sep. to lower serum triglycerides and total lipids was not enhanced by combined administration. Given alone, I (20-75 mg/kg) had fair hypocholesteremic and hypolipemic activities but was less effective than II (75-300 mg/kg).

A Simple, Sensitive, and Rapid Method for the Determination of Cotinine in Urine by High-Performance Liquid Chromatography with UV Detection

All Rights Reserved. A Simple, Sensitive, and Rapid Method for the Determination of Cotinine in Urine by High-Performance Liquid Chromatography with UV Detection. Rabbaa-Khabbaz, Lydia; Abi Daoud, Rita; Karam-Sarkis, Dolla ( Faculty of Pharmacy, Saint-Joseph University, Mathaf, Beirut 11-5076, Lebanon). Journal of Chromatographic Science, 44(9), 535-537 (English) 2006 Preston Publications. CODEN: JCHSBZ. ISSN: 0021-9665. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Cotinine levels in biol. fluids are a reliable indicator of the presence of nicotine. In this paper, a simple and sensitive high-performance liq. chromatog. (HPLC) procedure for the detn. of cotinine in urine following liq.-liq. extn. with dichloromethane in an alk. medium is described. Calibration curves show linearity over the 50 to 3000 ng/mL range with low intra- and interday variability as well as good selectivity and specificity. 2398-81-4 and 93479-97-1 are cas registry numbers of chemicals which are used as reagents here. No solid-phase extn. is performed because the liq. dichloromethane extn. step yields excellent results. This method is a good alternative for routine anal. of urinary cotinine in labs. where gas chromatog. or HPLC-mass spectrometry is not available. (c) 2006 Preston Publications. .