Reference

Effects of

Effects of .alpha.-flupenthixol on dopamine and 5-hydroxytryptamine responses of substantia nigra neurons. Dray, A.; Gonye, T. J.; Oakley, N. R. (Sch. Pharm., Univ. London, London, Engl. 18525-25-2 and 62-31-7 which are cas registry numbers are also used here.). Neuropharmacology, 15(12), 793-6 (English) 1976. CODEN: NEPHBW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) .alpha.-Flupenthixol-2HCl (I) [2413-38-9] (2mM) reversibly reduced the excitatory and inhibitory responses to dopamine-HCl [62-31-7] (0.2M) or 5-hydroxytryptamine bimaleinate (II) [18525-25-2] (0.2M) of substantia nigra neurons of the anesthetized cat. I also depressed both caudate- and raphe-evoked inhibition of substantia nigra neurons. There may therefore be distinct excitatory and inhibitory receptors for dopamine and II. I is a relatively unselective antagonist. .

Effect of chlorpromazine and other anti-psychotic drugs on mouse striatal tyramines

Effect of chlorpromazine and other anti-psychotic drugs on mouse striatal tyramines. Juorio, A. V. (Psychiatr. Res. Div., Univ. Hosp., Saskatoon, Sask., Can.). Life Sci., 20(10), 1663-7 (English) 1977. CODEN: LIFSAK. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The clin. active antipsychotic drugs chlorpromazine-HCl (I-HCl) [69-09-0], .alpha.-flupenthixol-2HCl [2413-38-9], (+)-butaclamol-HCl [55528-07-9] and haloperidol [52-86-8] specifically reduced the striatal p-tyramine (p-TA) [51-67-2] in the mouse. The m-tyramine (m-TA) concn. was not changed and consequently a fall in the p-TA/m-TA ratio was obsd. In contrast, the structurally related compds., promethazine, .beta.-flupenthixol, and (-)butaclamol, which lack antipsychotic properties, did not induce changes in the striatal tyramines concn.