Reference

Stability indicating HPLC-method for the determination of econazole nitrate in cream and lotion formulations

Stability indicating HPLC-method for the determination of econazole nitrate in cream and lotion formulations. Christinat, R.; Zulliger, H. W. (Pharm. Res. Dev. Dep., Cilag Ltd., Schaffhausen, Switz.). Arzneim.-Forsch., 34(5), 551-3 (English) 1984. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 63 A stability-indicating assay to monitor shelf lives of econazole nitrate (I) [24169-02-6] in cream (Pevaryl, Pevisone) and lotion formulations with validating data is described. The column was a m-Bondapak C18 with a UV detector at 220 nm. The mobile phase was ammonium carbonate-water-tetrahydrofuran, and the internal std. was miconazole nitrate in MeOH. A linearity of 5-15 mg I/g sample was obtained and no loss of I during sample prepn. was obsd. The relative std. deviation was 0.59, 0.52, and 0.97% for the 2 cream and lotion formulations, resp.

Medicated suppository

Medicated suppository. Niederer, Roland Rudolf; Zulliger, Hans Walter (Cilag A.-G., Switz.). Eur. Pat. Appl. EP 103995 A2 28 Mar 1984, 9 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, IT, LI, LU, NL, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: IC: A61K009-02. APPLICATION: EP 83-304847 23 Aug 1983. PRIORITY: US 82-411123 24 Aug 1982. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A suppository capable of releasing the active ingredient evenly over the walls of the rectal or vaginal cavity comprises by wt. an active ingredient 4-15, a mixt. of C10H20O2-C18H30O2 fatty acid triglycerides 60-90, a gel-forming agent 5-25, and a gel-dispersing agent 4-8%. Thus, a suppository contained econazole nitrate [24169-02-6] 150, polygel 300, colloidal silica 27, Witepsol H 19 [70322-06-4] 404.2, Wecobee FS [90803-96-6] 1682.4, and stearyl heptanoate [66009-41-4] 136.4 mg.