Detail of "2432-99-7"

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Lesions of the urinary tract produced in Fischer 344 rats and B6C3F1 mice after chronic administration of 11-aminoundecanoic acid

Lesions of the urinary tract produced in Fischer 344 rats and B6C3F1 mice after chronic administration of 11-aminoundecanoic acid. Dunnick, June K.; Huff, James E.; Haseman, Joseph K.; Boorman, Gary A. (Natl. Toxicol. Program, Natl. Inst. Environ. Health Sci., Research Triangle Park, NC 27709, USA). Fundam. Appl. Toxicol., 3(6), 614-18 (English) 1983. CODEN: FAATDF. ISSN: 0272-0590. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) 11-Aminoundecanoic acid [2432-99-7], was toxic to the urinary tract of both male and female mice and rats, when administered in the diet at 7500 or 15,000 ppm for 103-104 wk. Dose-related effects included a decrease in mean body wt. gain and in survival for male rats and for mice of each sex; increased incidence of hyperplasia of the transitional epithelium of the kidney in rats of each sex; increased incidence of calcification of the kidney in the female rats; increased incidence of hyperplasia of the urinary bladder in male rats; and mineralization of the kidney in mice of each sex. Transitional cell carcinomas of the urinary bladder of the male rat occurred with increased frequency in the high-dose group (control, 0/48; low-dose, 0/48; high-dose, 7/49). Addnl. evidence for carcinogenicity in the male rat was seen in the liver, where an increased frequency of neoplastic nodules was found in the treated animals (controls, 1/50; low-dose, 9/50; high-dose, 8/50). Therefore, 11-aminoundecanoic acid was carcinogenic for male rats, inducing transitional cell carcinomas in the urinary bladder and neoplastic nodules in the liver. The test chem. was not carcinogenic for female rats or for mice of either sex.

Monomeric emulsifiers, 2

Monomeric emulsifiers, 2. Hydrolytic stability. De Winter, Walter; Marien, August (R and D Lab., Agfa-Gevaert, Mortsel B 2510, Belg.). Makromol. Chem., Rapid Commun., 5(9), 593-6 (English) 1984. CODEN: MCRCD4. ISSN: 0173-2803. 93295-43-3 is also in the experiment. DOCUMENT TYPE: Journal CA Section: 35 (Chemistry of Synthetic High Polymers) Monomers H2C:CMeCONH(CH2)10CONHZSO3Na (Z = p-C6H4 or CH2CH2) were prepd. from H2C:CMeCOCl [920-46-7], H2N(CH2)10CO2H [2432-99-7], and p-(H2N)C6H4SO3NH4 [7301-03-3] or H2NCH2CH2SO3NH4 [93341-49-2]. The monomers were stable against hydrolysis and were easily polymerizable and copolymerizable with acrylic monomers (e.g., Et acrylate), giving stable latexes. .