Reference

Spectrophotometric determination of cephapirin, a cephalosporin antibacterial

Spectrophotometric determination of cephapirin, a cephalosporin antibacterial. Bodnar, J. E.; Evans, W. G.; Mays, D. L. (Bristol Lab., Bristol-Myers Co., Syracuse, N. Y., USA). J. Pharm. Sci., 66(8), 1108-11 (English) 1977. CODEN: JPMSAE. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) A simple and specific method for the quant. detn. of cephapirin Na (I Na salt) [24356-60-3], a cephalosporin antibacterial, in finished bulk and dosage forms is reported. The method is based on reproducible degrdn. under controlled conditions to an unidentified species, which is measured spectrophotometrically at 375 nm. The procedure can be performed manually on a short series of samples in .apprx.15 min or can be automated for large runs. Precursors and related substances show minimal interference. The coeff. of variation of the automated system is .apprx.1% within days and 1.3% among days.

Analysis of drug decomposition

Analysis of drug decomposition. XXXVII. Application of high-performance liquid chromatography in evaluating stability of some cephalosporin antibiotics in the solid state. Zajac, Maria; Molenda, Anna (Dep. Pharm. Chem., K. Marcinkowski Sch. Med., Poznan 60-780, Pol.). Acta Pol. Pharm., 43(5), 428-35 (Polish) 1986. CODEN: APPHAX. ISSN: 0001-6837. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 64 Decompn. of solid cefadroxil (I) [50370-12-2], cephaloridine (II) [50-59-9], cefsulodin Na (III) [52152-93-9], cefazoline Na (IV) [27164-46-1], cefoperazone Na (V) [62893-20-3], and cephapirin Na (VI) [24356-60-3] in presence of moisture was studied by HPLC. In dry air, the decompn. of I, II, and VI was autocatalytic, whereas that of III, IV, and V followed a 1st-order kinetics. 11111-12-9 and 52152-93-9 are also in the experiment. Both iodometric and spectrophotometric detn. of the Na salts in presence of their decompn. products was nonspecific. The decompn. products of I and II were H2O-insol. and, therefore, did not interfere with the den. by iodometry or spectrophotometry. When the subtractive procedure was applied, both detn. methods could be used for all the antibiotics under investigation. .