CAS No.24356-60-3,Cefapirin sodium Suppliers

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Basic Information

Molecular Structure:
CAS No.:	24356-60-3
Name:	Cefapirin sodium
Article Data:	1

Formula:	C₁₇H₁₇N₃O₆S·2Na
Molecular Weight:	445.452
Synonyms:	5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-, acetate (ester),monosodium salt (8CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R,7R)- (9CI);5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R-trans)-;Ambrocef;BLP1322;Brisfirina;Cef-Lak;Cefadyl;Cefaloject;Cefatrexyl;Cephapirin sodium;Cephatrexil;NSC179171;Piricef;Sodium cefapirin;Sodium cephapirin;
EINECS:	246-194-2
Boiling Point:	783.9 °C at 760 mmHg
Flash Point:	427.9 °C
Hazard Symbols:	Xn
Risk Codes:	36/37/38-42/43
Safety:	26-36
PSA:	179.33000
LogP:	-0.53050

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Specification

The Temocillin disodium salt, with the CAS registry number 24356-60-3, is also known as 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R,7R)- (9CI). Its EINECS number is 246-194-2. This chemical's molecular formula is C₁₇H₁₇N₃O₆S·2Na and molecular weight is 446.48. What's more, its systematic name is Sodium (6R,7R)-3-(acetoxymethyl)-8-oxo-7-{[(4-pyridinylsulfanyl)acetyl]amino}-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate. Its classification codes are: (1)Antibacterial; (2)Drug / Therapeutic Agent; (3)Human Data; (4)Reproductive Effect. This chemical is a cephalosporin antibiotic, partly plasma-bound, that is effective against gram-negative and gram-positive organisms.

Physical properties of Temocillin disodium salt are: (1)ACD/LogP: 0.792; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 9; (4)#H bond donors: 2; (5)#Freely Rotating Bonds: 8; (6)Polar Surface Area: 167.71 Å²; (7)Flash Point: 427.9 °C; (8)Enthalpy of Vaporization: 119.63 kJ/mol; (9)Boiling Point: 783.9 °C at 760 mmHg; (10)Vapour Pressure: 6.98E-26 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. It may cause sensitisation by inhalation and skin contact. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES: [Na+].O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)CSc3ccncc3)COC(=O)C)C([O-])=O
(2)Std. InChI: InChI=1S/C17H17N3O6S2.Na/c1-9(21)26-6-10-7-28-16-13(15(23)20(16)14(10)17(24)25)19-12(22)8-27-11-2-4-18-5-3-11;/h2-5,13,16H,6-8H2,1H3,(H,19,22)(H,24,25);/q;+1/p-1/t13-,16-;/m1./s1
(3)Std. InChIKey: VGEOUKPOQQEQSX-OALZAMAHSA-M

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	2500mg/kg (2500mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
man	TDLo	intramuscular	350mg/kg/6D (350mg/kg)	BLOOD: AGRANULOCYTOSIS	Antimicrobial Agents and Chemotherapy. Vol. 1, Pg. 174, 1972.
man	TDLo	intravenous	7429ug/kg/8W- (7.429mg/kg)	KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS	Drug Intelligence and Clinical Pharmacy. Vol. 21, Pg. 380, 1987.
mouse	LD50	intraperitoneal	8899mg/kg (8899mg/kg)		Drugs in Japan Vol. 6, Pg. 405, 1982.
mouse	LD50	intravenous	4600mg/kg (4600mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
mouse	LD50	oral	26088mg/kg (26088mg/kg)		Drugs in Japan Vol. 6, Pg. 405, 1982.
mouse	LD50	subcutaneous	13556mg/kg (13556mg/kg)		Drugs in Japan Vol. 6, Pg. 405, 1982.
rabbit	LD50	intravenous	3gm/kg (3000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rat	LD50	intraperitoneal	7850mg/kg (7850mg/kg)		Drugs in Japan Vol. 6, Pg. 405, 1982.
rat	LD50	intravenous	4580mg/kg (4580mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 29, Pg. 424, 1979.
rat	LD50	oral	16356mg/kg (16356mg/kg)		Drugs in Japan Vol. 6, Pg. 405, 1982.
rat	LD50	subcutaneous	> 14400mg/kg (14400mg/kg)		Drugs in Japan Vol. 6, Pg. 405, 1982.