Detail of "244-63-3"

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CAS Number:
244-63-3
Name:
9H-Pyrido[3,4-b]indole
Molecular Structure:
Formula:
C11H8 N2
Molecular Weight:
168.21
Synonyms:
2,9-Diazafluorene;2-Azacarbazole; Carbazoline; NSC 84417; Norharman; Norharmane; b-Carboline
EINECS:
205-959-0
Density:
1.301 g/cm³
Melting Point:
199-201 °C
Boiling Point:
391.3 °C at 760 mmHg
Flash Point:
182.1 °C
Appearance:
light yellow crystalline
Hazard Symbols:
Xn
Risk Codes:
22
Safety:
Poison by intravenous route. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NO_x. Details

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9H-Pyrido[3,4-b]indole-3-carboxamides: 9H-Pyrido[3,4-b]indole-3-carboxamides. (Council of Scientific and Industrial Research (India), India). Indian IN 157243 A 15 Feb 1986, 11 pp. (India) CODEN: INXXAP. CLASS: IC: C07D057-00. APPLICATION: IN 80-DE316 28 Apr 1980. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Pyridoindolecarboxamides I [R = CH2CO2H, NHC(S)NHAr, N:CHAr; Ar = (un)substituted Ph] and II (R1 = SH, alkylthio, alkylsulfonyl, SCH2CO2H), contraceptive occluding agents of the Fallopian tubes and vas deferens (no data), are prepd., e.g., by reaction of hydrazides with ArNCS or ArCHO. Thus, I (R = NH2) and PhNCS were refluxed in EtOH to give 72% I [R = NHC(S)NHPh], which was cyclized in refluxing 4% NaOH to give 82. 73834-74-9 which is the cas registry number of some chemical is mentioned.4% II (R1 = SH, Ar = Ph). Also prepd. were I (R = CH2CO2H, N:CHPh) and II [R1 = SEt, S(O)2Et, Ar = Ph]. .

Synthesis of substituted pyrido[3,4-b]indole-3-carboxamides and related compounds as benzodiazepine receptor agonists/antagonists: Synthesis of substituted pyrido[3,4-b]indole-3-carboxamides and related compounds as benzodiazepine receptor agonists/antagonists. Mehta, Pratibha; Saxena, Anil K.; Gulati, A.; Anand, Nitya (Med. Chem. Div., Cent. Drug Res. Inst., Lucknow 226 001, India). Indian J. Chem., Sect. B, 27B(2), 140-3 (English) 1988. CODEN: IJSBDB. ISSN: 0376-4699. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 9H-Pyrido[3,4-b]indole-3-carboxamides I (R = octylamino, morpholino, piperidino, etc.) have been prepd. by the condensation of Me 9H-pyrido[3,4-b]indole-3-carboxylate with the appropriate amine at 150° for 48 h. The receptor binding studies and electroencephalog. of these compds. show that some of them have promising benzodiazepine receptor agonistic and antagonistic activities.