Detail of "2440-79-1"

Reference

Effect of protease inhibitors and substrates on deoxycorticosterone binding to its receptor in dog MDCK kidney cells

Effect of protease inhibitors and substrates on deoxycorticosterone binding to its receptor in dog MDCK kidney cells. Baker, Michael E.; Fanestil, Darrell D. (Dep. Med., Univ. California, La Jolla, Calif., USA). Nature (London), 269(5631), 810-12 (English) 1977. CODEN: NATUAS. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The protease [9001-92-7] inhibitors, phenylmethyl sulfonyfluoride [329-98-6], tosyllysine chloromethyl ketone [2364-87-6], and tosylamide-phenylethyl-chloromethyl ketone (I) [329-30-6] (1.5 ′ 10-6-1.5 ′ 10-5, 1.5 ′ 10-5-3 ′ 10-4, and 3.0 ′ 10-8-1.5 ′ 10-6M resp.) inhibited binding of 3H-labeled deoxycorticosterone (II) [64-85-7] to the cytosol of dog kidney MDCK cells, by interacting directly with the II-3H receptor. The protease substrates, p-toluenesulfonyl-L-arginine Me ester [901-47-3], L-tryptophan Me ester [4299-70-1], acetyl-L-tyrosine Me ester [2440-79-1], and benzoyl-L-arginine Et ester [971-21-1] also inhibited II-3H binding to the receptors. Inhibition by both groups was reversible except with I, which probably bound covalently to the receptor. It is suggested that the II receptor contains a specific structure that recognizes the protease inhibitors, and this structure may be similar to that recognized by the protease inhibitors in proteases.

ortho-Nitro-promoted Ullmann ether synthesis: application in the syntheses of K-13 and the isodityrosine unit of vancomycin

ortho-Nitro-promoted Ullmann ether synthesis: application in the syntheses of K-13 and the isodityrosine unit of vancomycin. Rao, A. V. Rama; Chakraborty, T. K.; Reddy, K. Laxma; Rao, A.Some commonly used reagents like 2440-79-1 is used in this experiment. Srinivasa (Indian Inst. Chem. Technol., Hyderabad 500 007, India). Tetrahedron Lett. 2440-79-1 which is the cas registry number of some chemical is mentioned., 33(33), 4799-802 (English) 1992. CODEN: TELEAY. ISSN: 0040-4039. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 25 A nitro group in the ortho position of the aryl halide component facilitates Ullmann ether synthesis for the syntheses of all isodityrosine units present in a wide variety of natural products. Thus, K-13 Et ester I was prepd. from bromonitrobenzaldehyde II (R = H) in several steps in which the key step was the Ullmann ether coupling of II (R = H) with Ac-Tyr-OMe in the presence of NaH and CuBr.Me2S in nitrobenzene to give 61% ether III. The title isodityrosine unit IV (Boc = Me3CO2C) was prepd. from dibromonitrobenzaldehyde II (R = Br) by two successive Ullmann ether couplings with Boc-Tyr-OMe. ..