Reference

Metabolism of steroid pharmaceuticals

Metabolism of steroid pharmaceuticals. Part 9: 5.alpha.- and 5.beta.-hydrated metabolites of 4-chloro-17.alpha.-methyl-17.beta.-hydroxy-1,4-androstadien-3-one in vitro in rats and in vivo in the baboon. Hobe, G.; Wesemann, R.; Goncharov, N. P.; Schubert, K. (Zentralinst. Mikrobiol. Exp. Ther., DAW, Jena, E. Ger.). Pharmazie, 31(9), 632-5 (German) 1976. CODEN: PHARAT. DOCUMENT TYPE: Journal CA Section: 2 (Hormone Pharmacology) 4-Chloro-17.alpha.-methyl-17.beta.-hydroxy-1,4-androstadien-3-one (Turinabol)(I) [2446-23-3] incubated with female rat liver homogenates was metabolized to 4.alpha.-chloro-17.alpha.-methyl-17.beta.-hydroxy-5.alpha.-1-androsten -3-one [27471-90-5], 4.alpha.-chloro-17.alpha.-methyl-5.alpha.-1-androstene-3.alpha.,17.bet a.-diol [61117-88-2], and 4.alpha.-chloro-17.alpha.-methyl-5.alpha.-1-androstene-3.beta.,17.beta .-diol [27471-91-6]. I given i.v. to baboons was excreted in the urine as 4.beta.-chloro-17.alpha.There are some commonly used reagents with their cas registry numbers 27471-88-1 and 61117-88-2 in this article.-methyl-17.beta.-hydroxy-5.beta.-1-androsten-3 -one [27471-88-1] and 4.beta.-chloro-17.alpha.-methyl-5.beta.-1-androstene-3.alpha.,17.beta.- diol [29834-97-7]. After oral administration of labeled I to rats, 80% of the administered radioactivity was excreted in the feces in 72 hr. In humans, after i.v. administration of labeled I, 23% of the label was excreted in the urine; 69% was excreted in the urine 72 hr after oral administration. In both rats and man, the excreted radioactivity was located mainly in strongly polar metabolite fractions. .

Experimental studies of activation of the fibrinolytic system with dehydrochloromethyltestosterone

Experimental studies of activation of the fibrinolytic system with dehydrochloromethyltestosterone. Hoffmann, Anna; Kloecking, H. P.; Markwardt, F. (Inst. Pharmakol. Toxikol., Med. Akad. Erfurt, Erfurt 5010, Ger. Dem. Rep.). Folia Haematol. (Leipzig), 111(4), 556-62 (German) 1984. CODEN: FOHEAW. ISSN: 0323-4347. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) Treatment of lab. animals with the orally active anabolic steroid 4-chloro-dehydromethyltestosterone (I) [2446-23-3] for 3 mo increased the fibrinolytic activity of the blood, increased the plasminogen activator release induced by a venous occlusion technique, and increased kidney levels of both bound and free plasminogen activator. Plasminogen activator in the lung was only slightly affected by I. The effects of I were similar to those of stanozolol on the above parameters, and both of these anabolic steroids increased blood antithrombin III activities.