Reference

Antimicrobial agents

Antimicrobial agents. State-of-the-science review. Kornman, K. S. (Sch. Dent., Univ. Texas, San Antonio, TX, USA). Dent. Plaque Control Meas. Oral Hyg. Pract., Proc. Workshop, Meeting Date 1985, 121-42. Edited by: Loe, Harald; Kleinman, Dushanka V. IRL: Oxford, UK. (English) 1986. CODEN: 55HXAY. DOCUMENT TYPE: Conference; General Review CA Section: 1 (Pharmacology) A review with 132 refs. of antimicrobial agents that have been tested in controlled clin. trials for effects on supragingival plaque prevention, plaque mass, or plaque microbiol. These include antibiotics, enzymes, quaternary ammonium compds., phenolic compds., F- prepns., chlorhexidine [55-56-1], and sanguinarine [2447-54-3].

Detection and quantitative analysis of sanguinarine in edible oils

Detection and quantitative analysis of sanguinarine in edible oils. Balderstone, P.; Dyke, S. F. (Sch. Chem., Univ. Bath, Bath, Engl.). J. Chromatogr., 132(2), 359-62 (English) 1977. CODEN: JOCRAM. DOCUMENT TYPE: Journal CA Section: 17 (Foods) Sanguinarine [2447-54-3] in edible oils, an indication of adulteration with Argemone mexicana oil, was detected by placing a spot of the sample oil on a 750-.mu.m-thick layer of silica gel G and chromatographing with C6H6 and then at right angles with C6H6-MeOH (6:1). Sanguinarine gives an orange spot undr UV irradn. For quant. detn., the contaminated oil sample was reduced with NaBH4 to give dihydrosanguinarine, which was extd. with 2M HCl, neutralized with NaHCO3, extd. with CHCl3, evapd., and dissolved in EtOH. The ext. was chromatographed on silica gel with C6H6-MeOH (6:1), dried, irradiated with long-wavelength UV to oxidize dihydrosanguinarine to sanguinarine, which was removed from the plate, dissolved in acidified EtOH, and measured at 330 nm. The limit of detection was 10-9 g, and the recovery in the quant. procedure was 92.+-.5%.