Detail of "2448-68-2"

Reference

Effects of minor tranquilizers and neuroleptics on open-field behavior in rats

Effects of minor tranquilizers and neuroleptics on open-field behavior in rats. Honma, Takeshi; Kitagawa, Sumio (Pharm. Div., Sumitomo Chem. Co., Ltd., Takarazuka, Japan). Nippon Yakurigaku Zasshi, 73(3), 337-45 (Japanese) 1977. CODEN: NYKZAU. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Minor tranquilizers (diazepam (I) [439-14-5], nitrazepam [146-22-5], oxazepam [604-75-1], bromazepam [1812-30-2], medazepam [2898-12-6], fludiazepam [60918-52-7], meprobamate [57-53-4]) at low doses increased ambulation score to 145-288% of control rats. Nitrazepam, I and bromazepam increased the ambulation at lower doses to a greater extent than did the other drugs. Fludiazepam and nitrazepam showed a max. increase in ambulation at the same dose. Fludiazepam, nitrazepam and I proved to have potent inhibitory effects on defecation. Trifluperidol [749-13-3], haloperidol [52-86-8] and ID-4708 [50528-46-6] (a new butyrophenone deriv.) and chlorpromazine-HCl [69-09-0] when given at low doses reduced ambulation, while at higher doses defecation was inhibited. These 4 drugs reduced ambulation and restored defecation in methamphetamine treated rats. Clozapine [5786-21-0], thioridazine-HCl [130-61-0] and fluoropipamide-2HCl [2448-68-2] inhibited defecation at nearly the same doses which reduced ambulation in rats not given the methamphetamine treatment. These 3 drugs reduced ambulation, but did not produce a recovery in the defecation rates in methamphetamine-treated rats. Thus, neuroleptics such as clozapine, which rarely induce extrapyramidal side-effects when clin. prescribed, inhibit defecation at nearly the same doses which reduce ambulation. In methamphetamine-treated rats, haloperidol was 31 times more potent than was chlorpromazine in inhibiting activity obsd. with ambulation. This ratio in open-field test was close to the ratio of potency of these drugs as antipsychotic clin. prescribed agents.

Fluorescent properties of some butyrophenones

Fluorescent properties of some butyrophenones. Baeyens, W. (Fac. Pharm. Sci., State Univ. Ghent, Ghent, Belg.). Analyst (London), 102(1216), 525-30 (English) 1977. CODEN: ANALAO. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) The fluorescence properties of 8 neuroleptic butyrophenones, e.g. benperidol [2062-84-2], were detd. in various solvents and the effects of acidity were examd. Pipamperone [2448-68-2] exhibits a weak signal at all pH but the other ketones show moderate or strong fluorescence. The detection limits of the 4 strongly fluorescing ketones, benperidol, droperidol [548-73-2], azaperone [1649-18-9], and fluanisone [1480-19-9], are ~5 ′ 10-2 mg/mL, after extg. the 4-hydroxybenzoic acid ester preservatives in the liq. prepns. Azaperone fluoresces strongly in acids and has a detection limit of 10-2 mg/mL without removing preservatives.