Reference

Effect of panangin, orotic acid and potassium orotate on the absorbing capacity of the reticuloendothelium system

Effect of panangin, orotic acid and potassium orotate on the absorbing capacity of the reticuloendothelium system. Lazareva, D. N.; Plechev, V. V. (Bashk. Med. Inst., Ufa, USSR). Aktual. Vopr. Allerg., Immun. Zashch. Mekh. Org., 63-4. Edited by: Lotsmanov, Yu. A. Bashk. Gos. Med. Inst.: Ufa, USSR. (Russian) 1973. CODEN: 36ITAC. DOCUMENT TYPE: Conference CA Section: 3 (Biochemical Interactions) Orotic acid (I) [65-86-1] (60 and 400 mg/kg) administered orally to mice daily for 1 week increased the phagocytotic capacity of the reticuloendothelial system, a change which was prevented by pretreatment with hydrocortisone. K orotate [24598-73-0] and panangin [8076-65-1] did not affect the reticuloendothelial function.

Sensitivity to strophanthin during myocardial blood supply disturbances, during altered immunological response, and under the effect of some drugs

Sensitivity to strophanthin during myocardial blood supply disturbances, during altered immunological response, and under the effect of some drugs. Gendenshtein, E. I.; Volkova, N. D.; Oleinikova, E. A.; Novikova, L. V. (Mord. Univ. im. Ogareva, Saransk, USSR). Farmakol. Toksikol. (Moscow), 40(2), 174-77 (Russian) 1977. CODEN: FATOAO. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Occlusion of the coronary artery increased the sensitivity of cats to the arrhythmogenic effect of strophanthin [11005-63-3] but had no effect on tolerance to the lethal dose. K orotate [24598-73-0] (100 mg/kg/day for 6 days) given orally did not decrease the sensitivity to the tonic effect of strophanthin in normal or myocardially infarcted cats. Pretreatment with anapriline [318-98-9] (4 mg/kg) did not potentiate the ability of Na2EDTA [139-33-3] (100 mg/kg) to decrease strophanthin toxicity. Pretreatment with isadrine [7683-59-2] (8 mg/kg completely eliminated the effect of Na2 EDTA. Immunization of cats with homocardial antigen had a biphosic effect on the sensitivity to the toxic effects of strophanthin dependent on the duration of antigenic stimulation.