Reference

Preparation of a drug-induced allergic hepatic disorder model with penicillin as hapten

Preparation of a drug-induced allergic hepatic disorder model with penicillin as hapten. Mizoguchi, Yasuhiro; Iwasaki, Masashi; Tsutsui, Hiroko; Kobayashi, Kenzo; Monna, Tekeyuki; Morisawa, Seiji (Med. Sch., Osaka City Univ., Osaka 545, Japan). Osaka City Med. J., 37(2), 133-40 (English) 1991.In this article, certain chemicals are used. Some of their cas registry numbers are 6066-82-6 and 2462-31-9 CODEN: OCMJAJ. ISSN: 0030-6096. DOCUMENT TYPE: Journal CA Section: 14 (Mammalian Pathological Biochemistry) A drug-induced allergic hepatic disorder model was established using a hapten and carrier. Penicillin G was bound to glycine for the prepn. of N-hydroxy succinic imidylglycinyl benzylpenicillate (PG-Gly-OSu). Using this as the hapten and liver protein as the carrier, guinea pigs were sensitized with liver protein bound to PG-Gly-OSu. After 2 wk, the sensitized guinea pigs were directly challenged with hepatocytes bound to PG-Gly-OSu through a mesenteric vein and hepatocellular disorder was induced. When the sensitized guinea pigs were challenged with PG-Gly-OSu alone or with liver protein alone, hepatocellular disorder could not be induced. These results suggest that the combination of PG-Gly-OSu as the hapten and liver protein as the carrier elicits a hepatocellular disorder similar to drug-induced allergic hepatitis. .