Detail of "246852-12-0"

Reference

purification of amlodipine free base, derived from N-protected amlodipine, via recrystallization

purification of amlodipine free base, derived from N-protected amlodipine, via recrystallization. Spielmann, Daniel C.; Hoss, Ralf; Mueller, Beat W.; Oelting, Michael ( Siegfried Generics International A.-G., Switz.). PCT Int. Appl. WO 2005009960 A1 3 Feb 2005, 14 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (German). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D211-90. APPLICATION: WO 2004-CH457 19 Jul 2004. PRIORITY: CH 2003-1302 25 Jul 2003. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 63 A method for the purifn. 246852-12-0 and 74-84-0 which are cas registry numbers of chemicals are mentioned. of the deprotected free base of amlodipine, present in the reaction mixt. following deprotection of N-protected amlodipine, comprises (i) subjecting the reaction mixt. contg. the deprotected amlodipine free base, optionally after filtration, to evapn. to dryness, or removal of solvent, (ii) recrystn. of the residue thus obtained from a suitable solvent. .