CAS No.24697-74-3,Leonurine hydrochloride Suppliers

Products Categories

Pharmaceutical (133)
Plant Extract (37)
Organic Chemicals (29)
Others (21)
Reagent (4)
Materials (2)
Agrochemicals (1)
Food Additives (1)

Basic Information

Molecular Structure:
CAS No.:	24697-74-3
Name:	Leonurine hydrochloride
Article Data:	7

Formula:	C₁₄H₂₁N₃O₅
Molecular Weight:	311.338
Synonyms:	Leonurine;Benzoicacid, 4-hydroxy-3,5-dimethoxy-, ester with (4-hydroxybutyl)guanidine (8CI);Leonurine (7CI);Guanidine, (4-hydroxybutyl)-, 4-hydroxy-3,5-dimethoxybenzoate(8CI);Guanidine, (4-hydroxybutyl)-, 4-hydroxy-3,5-dimethoxybenzoate (ester)(8CI);4-Guanidino-1-butanol syringate;4-Hydroxy-3,5-dimethoxybenzoic acid d-guanidinobutyl ester;Leonurin;Syringic acid d-guanidinobutylester;[4-(4-Hydroxy-3,5-dimethoxybenzoyloxy)butyl]guanidine;
EINECS:	683-174-6
Density:	1.29 g/cm³
Melting Point:	191-193oC
Boiling Point:	531.6 °C at 760 mmHg
Flash Point:	275.3 °C
Appearance:	brown powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-24/25
PSA:	126.89000
LogP:	2.02040

Synthetic route

: 4-(2,3-bis(tert-butoxycarbonyl)guanidino)butyl 4-hydroxy-3,5-dimethoxybenzoate

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
With zinc dibromide In dichloromethane at 20℃;	93%

: S-methylisothiourea hemisulphate

: 18780-70-6
Leonuramin

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide at 120℃; for 6h;	65%

: 18780-70-6
Leonuramin

: 867-44-7
S-Methylisothiourea sulfate

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
In water; N,N-dimethyl-formamide at 120℃; for 6h;	65%

: 18780-70-6
Leonuramin

: 322474-21-5
N,N'-bis-Boc-S-methyl-isothiourea

A: 24697-74-3
Leonurine

B: 1260119-24-1
3,5-dimethoxy-4-hydroxybenzoic acid-4-(N,N'-diBoc-guanidino)butyl ester

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 60℃;	A 30% B 5%

...Expand

: 18780-68-2
4-ethoxycarbonyloxy-3,5-dimethoxy-benzoyl chloride

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: triethylamine; dmap / dichloromethane / 6 h / 0 - 20 °C 2.1: ammonium hydroxide / methanol / 4 h / 20 °C 2.2: Raney nickel / 10 h / 20 °C 3.1: water; N,N-dimethyl-formamide / 6 h / 120 °C View Scheme
Multi-step reaction with 4 steps 1: triethylamine; dmap / dichloromethane / 0 - 20 °C 2: ammonium hydroxide / methanol / 20 °C 3: hydrogen / methanol / 10 h / 25 °C / 760.05 Torr 4: N,N-dimethyl-formamide; water / 6 h / 120 °C View Scheme

: 18780-67-1
4-[(ethoxycarbonyl)oxy]-3,5-dimethoxybenzoic acid

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: thionyl chloride / 1 h / Reflux 2.1: triethylamine; dmap / dichloromethane / 6 h / 0 - 20 °C 3.1: ammonium hydroxide / methanol / 4 h / 20 °C 3.2: Raney nickel / 10 h / 20 °C 4.1: water; N,N-dimethyl-formamide / 6 h / 120 °C View Scheme
Multi-step reaction with 5 steps 1: thionyl chloride / Reflux 2: triethylamine; dmap / dichloromethane / 0 - 20 °C 3: ammonium hydroxide / methanol / 20 °C 4: hydrogen / methanol / 10 h / 25 °C / 760.05 Torr 5: N,N-dimethyl-formamide; water / 6 h / 120 °C View Scheme

: 530-57-4
3,5-dimethoxy-4-hydroxybenzoic acid

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
Multi-step reaction with 6 steps 1: sodium hydroxide / 6 h / Cooling 2: thionyl chloride / Reflux 3: triethylamine; dmap / dichloromethane / 0 - 20 °C 4: ammonium hydroxide / methanol / 20 °C 5: hydrogen / methanol / 10 h / 25 °C / 760.05 Torr 6: N,N-dimethyl-formamide; water / 6 h / 120 °C View Scheme
Multi-step reaction with 5 steps 1.1: dmap / dichloromethane / 20 h 2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 1 h / 20 °C 2.2: 6 h / 20 °C 3.1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 6 h 4.1: acetic acid; zinc / 2 h 5.1: N,N-dimethyl-formamide / 5 h / 140 °C View Scheme
Multi-step reaction with 4 steps 1: triethylamine / dichloromethane / 5 h / 20 °C 2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 20 °C 3: sodium hydroxide / methanol / 20 °C 4: zinc dibromide / dichloromethane / 20 °C View Scheme

: C17H23NO8

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: ammonium hydroxide / methanol / 20 °C 2: hydrogen / methanol / 10 h / 25 °C / 760.05 Torr 3: N,N-dimethyl-formamide; water / 6 h / 120 °C View Scheme

: C15H19NO7

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: trifluoromethylsulfonic anhydride; triethylamine / dichloromethane / 6 h 2: acetic acid; zinc / 2 h 3: N,N-dimethyl-formamide / 5 h / 140 °C View Scheme

: C15H21NO6

: 2986-19-8
carbamimidothioic acid methyl ester

: 24697-74-3
Leonurine

Conditions

Conditions	Yield
In N,N-dimethyl-formamide at 140℃; for 5h;	17 g

Country:
Business Type:
All

Lab/Research institutions

Trading Company

Manufacturers

Other
Certificate:
Manufacturer

Enterprise Authentication

ISO

GMP

FDA

HALAL

Display:default sort
Suppiers of more reward points first

New supplier

Total:151 Page 1 of 4 1 2 3 4 Next>>

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 24697-74-3

Specification

Leonurine hydrochloride(CAS NO.24697-74-3) is one of the chemical constituents of the South African plant Leonotis leonurus. IT is also called 4-hydroxy-3,5-dimethoxybenzoic acid d-guanidinobutyl ester; syringic acid d-guanidinobutyl ester; [4-(4-hydroxy-3,5-dimethoxybenzoyloxy)butyl]guanidine; 4-guanidino-1-butanol syringate. It is a mildly psychoactive alkaloid found in species Leonotis nepetifolia, Leonotis artemisia as well as other plants of family Lamiaceae. Leonurine hydrochloride is easily extracted into water, as well as from the essential oil of Leonurus sibiricus.

Physical properties about Leonurine hydrochloride are: (1)ACD/LogP: 2.503; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 0.50; (4)ACD/LogD (pH 7.4): 0.47; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 5.47; (8)ACD/KOC (pH 7.4): 5.01; (9)#H bond acceptors: 8; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 10; (12)Index of Refraction: 1.554; (13)Molar Refractivity: 76.902 cm³; (14)Molar Volume: 240.086 cm³; (15)Polarizability: 30.486 10-24cm³; (16)Surface Tension: 46.8089981079102 dyne/cm; (17)Density: 1.297 g/cm³; (18)Flash Point: 275.311 °C; (19)Enthalpy of Vaporization: 83.749 kJ/mol; (20)Boiling Point: 531.615 °C at 760 mmHg

Uses of Leonurine hydrochloride: Leonurine hydrochloride is used with blood stasis, swelling of the role of diuresis, it is a traditional healer. It can be inhibit platelet aggregation, prevent thrombosis; it also be used as peripheral vascular dilatation and reduce vascular resistance. At the last it can be certain antihypertensive.

You can still convert the following datas into molecular structure:
(1)InChI=1S/C14H21N3O5/c1-20-10-7-9(8-11(21-2)12(10)18)13(19)22-6-4-3-5-17-14(15)16/h7-8,18H,3-6H2,1-2H3,(H4,15,16,17);
(2)InChIKey=WNGSUWLDMZFYNZ-UHFFFAOYSA-N;
(3)SmilesC(c1cc(c(c(c1)OC)O)OC)(=O)OCCCCNC(=N)N;