Detail of "24719-82-2"

CAS Number:
24719-82-2
Name:
L-Threonine, N-[[(9-b-D-ribofuranosyl-9H-purin-6-yl)amino]carbonyl]-
Molecular Structure:
Formula:
C15H20 N6 O8
Molecular Weight:
412.3547
Synonyms:
Threonine,N-[(9-b-D-ribofuranosyl-9H-purin-6-yl)carbamoyl]-,L- (8CI); N-(6-Nebularinylcarbamoyl)threonine;N-(6-Purinylcarbamoyl)-L-threonine riboside; N-[(9-b-D-Ribofuranosyl-9H-purin-6-yl)carbamoyl]-L-threonine;N-[(9-b-D-Ribofuranosyl-9H-purin-6-yl)carbamoyl]threonine;N-[(9-b-D-Ribofuranosylpurin-6-yl)carbamoyl]threonine;N-[N-(9-b-D-Ribofuranosylpurin-6-yl)carbamoyl]threonine;N6-(N-Threonylcarbonyl)adenosine
Density:
1.96g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C

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Methods and test kit for diagnosing cancer in humans: Methods and test kit for diagnosing cancer in humans. Vold, Barbara Schneider (SRI International, USA). PCT Int. Appl. WO 8303903 A1 10 Nov 1983, 19 pp. DESIGNATED STATES: W: DE, GB, JP, SE; RW: FR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: IC: G01N033-50. APPLICATION: WO 83-US579 18 Apr 1983. PRIORITY: US 82-371287 23 Apr 1982. DOCUMENT TYPE: Patent CA Section: 9 (Biochemical Methods) Section cross-reference(s): 14 A method is described for diagnosing cancer by detg. the amt. of certain nucleosides in urine by immunoassay. 24719-82-2 which is the cas registry number of one of substances is just one of reagents here. For example, N-[9-(b-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine (t6A) was detd. in human urine by an (NH4)2SO4 RIA with antibodies to t6A-serum albumin conjugate and [3H]t6A as tracer. Elevated levels of t6A in urine were a clear marker for all cancers tested, except Hodgkins disease. .

The role of modifications in codon discrimination by tRNALysUUU: The role of modifications in codon discrimination by tRNALysUUU. Murphy, Frank V.; Ramakrishnan, Venki; Malkiewicz, Andrzej; Agris, Paul F. (Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, UK).There are some reagents with their cas registry numbers 72667-55-1 and 24719-82-2 are used in this study. Nature Structural & Molecular Biology, 11(12), 1186-1191 (English) 2004 Nature Publishing Group. CODEN: NSMBCU. ISSN: 1545-9993. DOCUMENT TYPE: Journal CA Section: 6 (General Biochemistry) The natural modification of specific nucleosides in many tRNAs is essential during decoding of mRNA by the ribosome. For example, tRNALysUUU requires the modification N6-threonylcarbamoyladenosine at position 37 (t6A37), adjacent and 3' to the anticodon, to bind AAA in the A site of the ribosomal 30S subunit. Moreover, it can only bind both AAA and AAG lysine codons when doubly modified with t6A37 and either 5-methylaminomethyluridine or 2-thiouridine at the wobble position (mnm5U34 or s2U34). Here we report crystal structures of modified tRNA anticodon stem-loops bound to the 30S ribosomal subunit with lysine codons in the A site. These structures allow the rationalization of how modifications in the anticodon loop enable decoding of both lysine codons AAA and AAG. .