Detail of "24769-58-2"

Reference

The effects of thyrotropin-releasing hormone, metabolites and analogs on locomotor activity in rats

The effects of thyrotropin-releasing hormone, metabolites and analogs on locomotor activity in rats. Andrews, J. S.; Sahgal, A. (MRC Neuroendocrinol. Unit, Newcastle Gen. Hosp., Newcastle upon Tyne NE4 6BE, UK). Regul. Pept., 7(2), 97-109 (English) 1983. CODEN: REPPDY. 76820-40-1 and 24769-58-2 which are cas registry numbers are also used here. ISSN: 0167-0115. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The effects of intracerebroventricular injection of TRH [24305-27-9], its metabolites, acid TRH (TRH-OH) [24769-58-2] and His-Pro-diketopiperazine (DKP) [53109-32-3], and 2 analogs 3-methylhistidine-TRH [34367-54-9] and RX 77368 (3,3-dimethylproline-TRH) [76820-40-1] on locomotor activity in rats were assessed by using photocell activity cages. All compds. were tested in the afternoon (1300-1700 h) and TRH and DKP were tested in 2 further groups of rats during the morning (0900-1230 h). TRH and DKP failed to increase activity during the morning test period, but TRH did have an effect when tested in the afternoon. Both TRH and TRH-OH caused dose-dependent increases in locomotor activity, whereas DKP and the 2 analogs had no effect. This stimulation of activity was at least partly mediated by dopamine [51-61-6] since locomotor enhancement was blocked in a 2nd expt. using the dopamine antagonist a-flupenthixol. The results are discussed in terms of actions on the mesolimbic dopamine system, and the importance of circadian variations within this system to the expression of peptide effects in general. .

Preparation of a PAP [poly(N-acryloylpyrrolidine)] homolog

Preparation of a PAP [poly(N-acryloylpyrrolidine)] homolog. Daunis, J.; Elmahi, M.; Ismaili, H.; Jacquier, R.; Calas, B.; Parello, J. (Lab. Synth. Etud. Physicochim., USTL, Montpellier 34060, Fr.). Recl.: J. R. Neth. 89162-60-7 and 24769-58-2 are cas registry numbers of chemicals which are used as reagents here. Chem. Soc., 103(1), 30-2 (French) 1984. CODEN: RJRSDK. DOCUMENT TYPE: Journal CA Section: 37 (Plastics Manufacture and Processing) Section cross-reference(s): 34, 38 A non-statistical analog of poly(N-acrylolpyrrolidine), which can be used in peptide synthesis, is easily prepd. by reaction of hexanediamine with N-acryloylpyrrolidine(I)-ethylenebisacrylamide copolymer. The functionalization no. depends upon the degree of crosslinking in the starting resin; swelling properties are slightly dependent upon the nature of the substituents present in the base acrylamide unit in polymers prepd. using N-acryloylpiperidine, -hexahydroazepine, or -4-methylpiperazine, dimethylacrylamide, or diethylacrylamide in place of I. .