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| CAS No.: | 248282-01-1 |
|---|---|
| Name: | Paquinimod |
| Article Data: | 4 |
| Molecular Structure: | |
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| Formula: | C21H22N2O3 |
| Molecular Weight: | 350.417 |
| Synonyms: | N-ethyl-N-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide;N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide;Paquinimod [INN];UNII-HB76GLG27V;Paquinimod;N-ethyl-N-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide;N-ethyl-N-phenyl-1,2-dihydro-5-ethyl-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide; |
| Density: | 1.267g/cm3 |
| Boiling Point: | 487.259oC at 760 mmHg |
| Flash Point: | 248.486oC |
| PSA: | 62.54000 |
| LogP: | 3.47320 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 1354639-60-3
1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxylic acid methyl ester
- 103-69-5
N-ethyl-N-phenylamine
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| In n-heptane for 2h; Product distribution / selectivity; Reflux; Molecular sieve; | 93% |
- 103-69-5
N-ethyl-N-phenylamine
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| With thionyl chloride; triethylamine In dichloromethane at 0 - 20℃; for 4.5h; |
- 34934-06-0
5-ethyl-1H-benzo[d][1,3]oxazine-2,4-dione
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: NaH / dimethylformamide / 5 h / 20 °C 2: NaH / dimethylformamide / 5 h / 85 °C 3: HCl / acetic acid / 6 h / 60 °C 4: SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1: potassium carbonate / N,N-dimethyl-formamide 2: sodium methylate / N,N-dimethyl-formamide 3: n-heptane / 2 h / Reflux; Molecular sieve View Scheme |
- 66232-56-2
6-ethyl-anthranilic acid
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: dioxane / 1 h / 20 °C 2: NaH / dimethylformamide / 5 h / 20 °C 3: NaH / dimethylformamide / 5 h / 85 °C 4: HCl / acetic acid / 6 h / 60 °C 5: SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme | |
| Multi-step reaction with 4 steps 1: chloroformic acid ethyl ester / 1,4-dioxane 2: potassium carbonate / N,N-dimethyl-formamide 3: sodium methylate / N,N-dimethyl-formamide 4: n-heptane / 2 h / Reflux; Molecular sieve View Scheme |
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: NaH / dimethylformamide / 5 h / 85 °C 2: HCl / acetic acid / 6 h / 60 °C 3: SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme |
- 675574-87-5
ethyl 5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-1-oxo-3-quinolinecarboxylate
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: HCl / acetic acid / 6 h / 60 °C 2: SOCl2; Et3N / CH2Cl2 / 4.5 h / 0 - 20 °C View Scheme |
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| With sodium hydroxide; calcium acetate In ethanol; water at 20 - 70℃; for 1.08333h; pH=7.5; | 98% |
| Stage #1: N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide With sodium hydroxide In ethanol; water pH=7.5; Stage #2: With calcium acetate In ethanol; water | 98% |
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
- 862462-44-0
N-ethyl-N-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide lithium salt
| Conditions | Yield |
|---|---|
| With lithium hydroxide In ethanol; water for 4h; | 84% |
| With lithium hydroxide In ethanol; water for 4h; | 84% |
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| With sodium hydroxide; zinc diacetate In ethanol; chloroform; water for 0.166667h; | 76% |
| Stage #1: N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide With sodium hydroxide In ethanol; water Stage #2: With zinc diacetate In ethanol; chloroform; water for 0.166667h; | 76% |
- 71-23-8
propan-1-ol
- 248282-01-1
N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide
| Conditions | Yield |
|---|---|
| With hydrogenchloride In water at 45 - 60℃; for 4h; Reactivity; | |
| With hydrogenchloride at 45 - 60℃; for 4h; Reactivity; |
- Total:24 Page 1 of 1 1
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