Detail of "25014-41-9"

Reference

Hemodialysis leukopenia and complement function with different dialyzers

Hemodialysis leukopenia and complement function with different dialyzers. Amadori, Alberto; Candi, Paolo; Sasdelli, Mauro; Massai, Graziella; Favilla, Stefania; Passaleva, Angelo; Ricci, Mario (Dep. Clin. Immunol., Univ. Florence, Florence, Italy). Kidney Int., 24(6), 775-81 (English) 1983. CODEN: KDYIA5. ISSN: 0085-2538. DOCUMENT TYPE: Journal CA Section: 15 (Immunochemistry) The relation between leukopenia and the complement system during hemodialysis was re-examd. by studying not only the in vivo effects of 4 different dialyzer membranes (cellulose hydrate, cuprophan, cellulose acetate, and polyacrylonitrile) on leukocyte counts and complement levels, but esp. by investigating the effects of these membranes on complement function in vitro. Whereas from in vivo studies no definite conclusions could be drawn, in vitro investigations provided clear-cut information. When more sophisticated tech. approaches were undertaken, it became evident that hemodialysis leukopenia has to be thought of in terms of chemotactic factor generation. In fact, a strict correlation was demonstrated between the degree of leukopenia induced by the dialyzers tested and the ability of the relative membrane to generate chemotactic activity in vitro.There are some commonly used reagents with their cas registry numbers 9004-35-7 and 25014-41-9 in this article. Moreover, the previously obsd. ability of the polyacrilonitrile membrane to induce a decrement in complement function was due to the ability of polyacrilinitrile to adsorb complement activity and did not correspond to effective complement consumption. This finding explained why polyacrilonitrile dialysis is not accompanied by a decrease in circulating granulocytes. These data point to a pivotal role of the complement system in the pathogenesis of hemodialysis leukopenia. .

Anaphylatoxin formation during hemodialysis: effects of different dialyzer membranes

Anaphylatoxin formation during hemodialysis: effects of different dialyzer membranes. Chenoweth, Dennis E.; Cheung, Alfred K.; Henderson, Lee W. (Dep. Pathol., Veterans Adm. Med. Cent., San Diego, CA, USA). Kidney Int., 24(6), 764-9 (English) 1983. CODEN: KDYIA5. ISSN: 0085-2538. DOCUMENT TYPE: Journal CA Section: 15 (Immunochemistry) Measurable complement activation resulting in the formation of both C3a and C5a anaphylatoxins was obsd. in 12 patients undergoing maintenance dialysis treatment with cuprophan hollow fiber dialyzers. Specific RIA measurements demonstrated that these patients displayed elevated levels of C3a in the venous (outflow) line of the dialyzer after only 2 min of dialysis. During hemodialysis, venous plasma C3a levels continued to increase and became maximally elevated after 15 min. Thereafter, C3a concns. gradually declined, suggesting that the rate of complement activation abates with continued cuprophan hemodialysis. Complement activation, as judged by venous plasma C3a levels, was also temporally correlated with hemodialysis leukopenia. The factor believed to be responsible for pulmonary vascular leukosequestration, C5a, could also be detected in venous plasma, but levels of this antigen were not strikingly elevated until the later stages of dialysis. By contrast, 6 patients dialyzed with polyacrylonitrile dialyzers failed to exhibit hemodialysis leukopenia and displayed only very modest increases in their plasma C3a levels during the initial phases of hemodialysis. Thus, anaphylatoxin formation during hemodialysis is a transient phenomenon and the biocompatibility of dialysis membranes, as reflected by their complement activating potential, may be significantly different.Except for chemicals metioned above, 25014-41-9 and 80295-42-7 are also used. .