Reference

5-Phenyl-2-benzazepine derivatives

5-Phenyl-2-benzazepine derivatives. (Sanwa Kagaku Kenkyusho Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59013761 A2 24 Jan 1984 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D223-16. ICA: A61K031-55.Several substances like 25026-34-0 may be metioned in this study. APPLICATION: JP 82-122232 15 Jul 1982. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 Analgesic (data shown by Haffner and AcOH writhing methods) title compds. I, (R = p-R1C6H4CH2CH2 where R1 = Cl, OH, NO2, NH2) were prepd. by reaction of I (R = H) (II) with p-R2C6H4CH2COX (III, R2 = Cl, OAc, NO2; X = halo) in the presence of reducing agent optionally followed by redn. Thus, 2,6 g III (R2 = X = Cl) reacted with 3 g II.HCl in CHCl3 contg. Et3N for 1 h and the product was refluxed with LiAlH4 in THF to give 55.8% I (R = p-ClC6H4CH2CH2), which was converted to its HCl salt. .