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25046-79-1

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Basic Information
CAS No.: 25046-79-1
Name: glisoxepide
Article Data: 5
Molecular Structure:
Molecular Structure of 25046-79-1 (glisoxepide)
Formula: C20H27 N5 O5 S
Molecular Weight: 449.531
Synonyms: Urea,1-(hexahydro-1H-azepin-1-yl)-3-[[p-[2-(5-methyl-3-isoxazolecarboxamido)ethyl]phenyl]sulfonyl]-(8CI); 4-[4-[b-(5-Methylisoxazole-3-carboxamido)ethyl]phenylsulfonyl]-1,1-hexamethylenesemicarbazide;BS 4231; Glisepin; Glisoxepid; Glisoxepide; Pro-Diaban; Pro-Diaben; RP 22410
Density: 1.37g/cm3
Melting Point: 189°
Boiling Point: °Cat760mmHg
Flash Point: °C
Safety: Poison by intravenous route. When heated to decomposition it emits very toxic fumes of NOx and SOx. Used as an antidiabetic agent.
PSA: 142.02000
LogP: 3.92580
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Chemistry

IUPAC Name: N-[2-[4-(Azepan-1-ylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide
Synonyms of Pro-Diaban (CAS NO.25046-79-1) : 1-(Hexahydro-1H-azepin-1-yl)-3-[[p-[2-(5-methyl-3-isoxazolecarboxamido)ethyl]phenyl]sulfonyl]urea ; 3-Isoxazolecarboxamide, N-[2-[4-[[[[(hexahydro-1H-azepin-1-yl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl- ; 4-[4-[b-(5-Methylisoxazole-3-carboxamido)ethyl]phenylsulfonyl]-1,1-hexamethylenesemicarbazide ; N-{2-[4-({[(Azepan-1-ylamino)carbonyl]amino}sulfonyl)phenyl]ethyl}-5-methylisoxazole-3-carboxamide
InChI:InChI=1/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27)
CAS NO:25046-79-1
Molecular Formula:C20H27N5O5S                    
Molecular Weight :449.5239                                     
Molecular Structure :
EINECS: 246-579-5
Index of Refraction:1.617
Surface Tension: 67.2 dyne/cm 
Density: 1.37 g/cm3 

Uses

 Pro-Diaban (CAS NO.25046-79-1) is used as oral blood glucose lowering drugs.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral > 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974.
dog LD50 oral > 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974.
mouse LD50 intravenous 283mg/kg (283mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974.
rabbit LD50 oral > 4gm/kg (4000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974.
rat LD50 intravenous 196mg/kg (196mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974.
rat LD50 oral > 10gm/kg (10000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 24, Pg. 409, 1974.

Safety Profile

Poison by intravenous route. When Pro-Diaban (CAS NO.25046-79-1) is heated to decomposition, it emits very toxic fumes of NOx and SOx. Used as an antidiabetic agent.