Detail of "2508-86-3"

Reference

Chromosome tests with 134 compounds on Chinese hamster cells in vitro - a screening for chemical carcinogens

Chromosome tests with 134 compounds on Chinese hamster cells in vitro - a screening for chemical carcinogens. Ishidate, Motoi, Jr.; Odashima, Shigeyoshi (Dep. Chem. Pathol., Natl. Inst. Hyg. Sci., Tokyo, Japan). Mutat. Res., 48(3-4), 337-53 (English) 1977. CODEN: MUREAV. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Section cross-reference(s): 17, 63, 5 Chromosomal aberration tests in vitro were carried out on Chinese hamster cells grown in culture with various chems., including carcinogenic N-nitroso compds. and their related derivs., food additives, medical drugs, pesticides and other chems. commonly used in labs. or industries. Of the 134 chems. tested, 63 gave neg. results in the test system even with doses at which the cell growth was markedly inhibited. Nearly all compds. known to be mutagenic in bacteria were also pos. in this system. Both urethane [51-79-6] and diethylstilbestrol [56-53-1] were pos., even though they are known to be carcinoenic but not mutagenic in bacteria. Compds. such as N-alkyl-N'-nitrogunidines, barbital [57-44-3], Na benzoate [532-32-1], saccharin sodium [128-44-9], NaNO2, NaNO3, and 4-aminoquinoline-1-oxide [2508-86-3] were pos. in the chromosome tests, but they have not been conclusively tested for their carcinogenicity.

Excision repair of DNA base damage in human cells treated with the chemical carcinogen 4-nitroquinoline 1-oxide

Excision repair of DNA base damage in human cells treated with the chemical carcinogen 4-nitroquinoline 1-oxide. Ikenaga, Mituo; Takebe, Hiraku; Ishii, Yutaka (Fac. Med., Osaka Univ., Osaka, Japan). Mutat. Res., 43(3), 415-27 (English) 1977. CODEN: MUREAV. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Excision repair of DNA damage produced by 4-nitroquinoline 1-oxide (I) [56-57-5], was compared in a normal human amnion FL cell line and a xeroderma pigmentosum (XP) cell line unable to repair UV-induced pyrimidine dimers. DNA was extd. from FL and XP cells anal. in order to quantitate the initial formation of I damage and subsequent disappearance during post-incubation. Two peaks of stable I-guanine adduct appeared on the chromatogram, together with 1 peak of stable I-adenine adduct and a peak due to 4-aminoquinoline 1-oxide (4AQO) [2508-86-3] released from a labile fraction of I-guanine adduct during hydrolysis. The 3 kinds of stable I-purine adduct disappeared from DNA of the FL cells at almost the same rate of about 60% during 24-h postincubation in culture medium, and 4AQO disappeared somewhat faster. In the XP cells, however, the stable adducts did not disappear from DNA, whereas about 40% of the 4AQO-releasing adduct disappeared from DNA. These findings at the mol. level quant. parallel the previous findings at the cellular level that the XP cells are several times as sensitive as normal cells to killing by I; I-induced lethality in human cells seems to be due mainly to the 4 kinds of I-purine adduct as it is in E. coli, and the adducts are excisable by the same excision-repair mechanism that works on pyrimidine dimers.