Detail of "25092-41-5"

CAS Number:
25092-41-5
Name:
19-Norpregn-4-ene-3,20-dione,17-(acetyloxy)-11-methyl-, (11b)-
Superlist Name:
Norgestomet
Molecular Structure:
Formula:
C₂₃H₃₂O₄
Molecular Weight:
372.50
Synonyms:
19-Norpregn-4-ene-3,20-dione,17-hydroxy-11b-methyl-,acetate (8CI);17a-Acetoxy-11b-methyl-19-norpregn-4-ene-3,20-dione;Norgestomet;Norprogesterone;SC 21009;? Norgestomet;
EINECS:
246-611-8
Density:
1.14g/cm³
Boiling Point:
495.8°Cat760mmHg
Flash Point:
214.1°C

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Thermodynamics of controlled drug release from polymeric delivery devices: Thermodynamics of controlled drug release from polymeric delivery devices. Chien, Yie W. (Searle Lab., G. D. Searle and Co., Skokie, Ill., USA). 56-47-3 and 72-33-3 are cas registry numbers. These chemicals are also mentioned in this article. ACS Symp. Ser., 33(Controlled Release Polym. Formulations, Symp., 1976), 53-71 (English) 1976. CODEN: ACSMC8. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Norgestomet [25092-41-5] release from a silicone polymer matrix in vitro was initially predominantly a partition controlled process in the hydrodynamic diffusion layer and in the steady-state was mainly a matrix-controlled process in the drug depletion zone. Mechanistically, norgestomet release required 3 energy-activated steps: (1) drug dissocn. from a crystal lattice required a dissocn. energy of 14.12 Kcal/mol, (2) drug dissocn. in a silicone polymer or in an elution medium required a solvation energy of 6.60 and 8.82 Kcal/mol., resp., and (3) drug diffusion in a polymer matrix or soln. phase required an activation energy of 3.70 and 3.85 Kcal/mol., resp. .

Superovulation in beef cattle with PMSG and prostaglandins or progestins: Superovulation in beef cattle with PMSG and prostaglandins or progestins. Voss, H. J.; Olivera-Angel, M.; Holtz, W. (Inst. Tierzucht Haustiergenet., Univ. Goettingen, Goettingen D-3400, Fed. Rep. Ger.). Theriogenology, 20(6), 615-25 (English) 1983. CODEN: THGNBO. ISSN: 0093-691X. DOCUMENT TYPE: Journal CA Section: 2 (Mammalian Hormones) The ovarian response to 2000 IU pregnant mare serum gonadotropin (PMSG) [9002-70-4] in 76 suckled cows and 153 heifers synchronized by either progesterone [57-83-0], a synthetic gestagen (Norgestomet [25092-41-5]), prostaglandin F2a [551-11-1], or a prostaglandin analog (Estrumate [55028-72-3]) was recorded after slaughter. The proportion of animals responding with 31 ovulation was 82-92% except for heifers treated with Estrumate (56%). Heifers had nearly twice as many ovulations as cows (11.9 vs. 6.8). The response was slightly more consistent in gestagen-synchronized animals; nevertheless, individual variation was considerable.