Reference

Cyclopropane derivatives useful as drugs

Cyclopropane derivatives useful as drugs. Cousse, Henri; Mouzin, Gilbert (Fabre, Pierre, S. A.Some commonly used reagents like 75-87-6 is used in this experiment., Fr.). Fr. Demande FR 2314708 14 Jan 1977, 19 pp. (French). (France). CODEN: FRXXBL. CLASS: IC: A61K031-00. APPLICATION: FR 75-18711 16 Jun 1975. DOCUMENT TYPE: Patent CA Section: 24 (Alicyclic Compounds) Section cross-reference(s): 63 Cyclopropanemethanol I esterified acid chlorides to give esters II [R = substituted Ph, PhNH, NH2, 10-phenothiazinyl, 4-ClC6H4OCMe2, C(OH)Ph2, 3-pyridyl], some of which showed sedative and tranquilizer activity; I was converted to I oxime, which also showed the above activity. Condensation reaction of pinacolone with epichlorohydrin yielded I. .

Preparation of azolopyrimidines as cardiovascular agents

Preparation of azolopyrimidines as cardiovascular agents.. Tsuda, Yoshinao; Mishina, Tadashi; Obata, Minoru; Araki, Kazuhiko; Inui, Jun; Nakamura, Tadao (Yoshitomi Pharmaceutical Industries, Ltd., Japan). Eur. Pat. Appl. EP 217142 A2 8 Apr 1987, 130 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, NL, SE. (European Patent Organization) CODEN: EPXXDW. CLASS: ICM: C07D487-04. ICS: A61K031-505. ICI: C07D487-04, C07D239-00, C07D231-00; C07D487-04, C07D239-00, C07D235-00; C07D487-04, C07D249-00, C07D239-00. APPLICATION: EP 86-111938 28 Aug 1986. PRIORITY: JP 85-218306 30 Sep 1985; JP 86-98499 28 Apr 1986. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The title compds. [I; R = H, cycloalkyl, (un)substituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, PhCO; R1 = H, acyl, cyano, NO2, (un)modified CO2H; R2 = halo, cyano, CHO, amino, cycloalkyl, (un)substituted alkyl, Ph, aralkyl; R3 = H, alkoxycarbonyl, acyl, heteroaroyl, (un)substituted alkyl, aralkyl; 31 of X, Y, Z = N, the remainder = R4C; R4 = H, halo, NO2, cycloalkyl, alkenyl, alkynyl, (un)modified CO2H, (un)substituted alkyl, alkoxy, alkylthio, etc.] were prepd. as cardiovascular agents (no data). Cyclopropanemethanol was esterified with diketene and the resulting acetoacetate was condensed with 2-F3CC6H4CHO to give cinnamate II. The latter was cyclocondensed with 3-aminopyrazole to give pyrazolo[1,5-a]pyrimidine-6-carboxylate III.Except for chemicals metioned above, 108407-55-2 is also used. .