Detail of "2525-62-4"

Reference

Inhibition of yeast respiration and fermentation by benomyl, carbendazim, isocyanates, and other fungicidal chemicals

Inhibition of yeast respiration and fermentation by benomyl, carbendazim, isocyanates, and other fungicidal chemicals. Chiba, Mikio; Bown, Alan W.; Danic, David (Res. Stn., Agric. Canada, Vineland Station, ON L0R 2E0, Can.).Chemicals with cas numbers 10605-21-7 and 17804-35-2 also play role. Can. J. Microbiol., 33(2), 157-61 (English) 1987. CODEN: CJMIAZ. ISSN: 0008-4166. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Section cross-reference(s): 4 The inhibition of yeast (Saccharomyces cerevesiae) metab. by fungicidal chem. was investigated. Glucose- or ethanol-dependent yeast respiration was measured with an O electrode, and manometric detn. of CO2 release was used to measure fermn. Both respiration and fermn. were inhibited more by benomyl [17804-35-2] than by identical molar concns. of its breakdown product, carbendazim [10605-21-7]. Butyl isocyanate [111-36-4], another benomyl breakdown product, inhibited respiration more but inhibited fermn. less than the parent compds. Of the isocyanates tested, hexyl isocyanate [2525-62-4] was the most inhibitory towards both activities. Captan [133-06-2] was more active and iprodione [36734-19-7] less active than benomyl. Because benomyl rapidly broke down to carbendazim when it was prepd. in 80% ethanol, only 59% of the dissolved benomyl was intact when it was added to yeast to det. its effect on respiration or fermn. .

Guinea pig pulmonary response to sensitization by five preformed monoisocyanate-ovalbumin conjugates

Guinea pig pulmonary response to sensitization by five preformed monoisocyanate-ovalbumin conjugates.Some chemicals with cas registry numbers like 72641-12-4 and 92199-61-6 are also used. De Ceaurriz, Jacques; Ducos, Philippe; Micillino, Jean Claude; Gaudin, Rene; Cavelier, Claude (Inst. Natl. Rech. Sec., Vandoeuvre 54500, Fr.). Toxicology, 43(1), 93-101 (English) 1987. CODEN: TXCYAC. ISSN: 0300-483X. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The ability of 5 dissimilar monoisocyanates conjugated to ovalbumin (OA) as a carrier protein to induce pulmonary hypersensitivity towards the hapten specific component was assessed by using a previously described method based on the detn. of a respiratory index (RI) in the guinea pig. The test chem. included p-tolyl [622-58-2] and hexylmonoisocyanate [2525-62-4] (TMI and HMI), 4-isocyanatodiphenylmethane (IDM) [1823-37-6], 4-isocyanato-4'-methyldiphenylmethane (IMDM) [107997-84-2], and 1-isocyanatomethyl-1,3,3-trimethylcyclohexane (IMTC)(I) [107997-85-3]. Guinea pigs were exposed daily to an aerosol of the OA conjugate of each monoisocyanate up to ￡15 days. Increases in respiratory rate and/or respiratory collapse occurred in the guinea pigs exposed to TMI-OA and HMI-OA conjugates by days 9 and 15, with RI values of 155 and 177, resp.. The greatest mean RI values in guinea pigs exposed to IDM-OA, IMDM-OA, and IMTC-OA conjugates to day 15 were 20, 25, and 22, resp., and were not indicative of any pulmonary reaction. Guinea pigs exposed in parallel to each test conjugate did not exhibit any pulmonary reaction when they were exposed to OA on the challenge days. All these findings evidence pulmonary hypersensitivity as the result of exposure to TMI-OA and HMI-OA conjugates and suggest a high degree of conjugation and strong linkage of all the monoisocyanates with OA. The difference between the no. of days to the onset of pulmonary reaction to TMI-OA and HMI-OA conjugates, and the lack of pulmonary reaction to IDM-OA, IMDM-OA, and IMTC-OA conjugates within the exptl. period suggest the influence of the nature of the haptenic portion on the lapse of time required for pulmonary response to OA preformed conjugates and point to the possibility of discriminating between the allergenic potential of the test materials on this basis. .