Detail of "25322-63-8"

Reference

Diffusivity and permeability of poly(a-amino acid) membranes to gases

Diffusivity and permeability of poly(a-amino acid) membranes to gases. Nakagawa, Tsutomu; Fujiwara, Y.Some chemicals with cas registry numbers like 25322-63-8 and 26062-47-5 are also used.; Minoura, N. (Fac. Eng., Meiji Univ., Kawasaki, Japan). J. Membr. Sci., 18, 111-27 (English) 1984. CODEN: JMESDO. ISSN: 0376-7388. DOCUMENT TYPE: Journal CA Section: 66 (Surface Chemistry and Colloids) The diffusivity and permeability, which characterize transport in poly(a-amino acid) membranes were detd. for He, H, Ar, O, N, and CO2 at 10-60°. The membranes of 6 poly(a-amino acid)s, namely poly(L-leucine)(PLL), poly(g-methyl-L-glutamate)(PMLG), poly(L-methionine)(PMt), poly(g-benzyl-L-glutamate)(PBLG), poly(Ne-carbobenzoxy-L-lysine)(PLy-Z), and poly(g-L-glutamic acid)(PG) were synthesized. In order to elucidate the effect of the side chain on transport, membranes were used whose polymer main chain is a rigid a-helical structure. The side chains have a great influence on transport properties; for example, the permeabilities of N were distributed in the range 2 ′ 10-10 to 1 ′ 10-14 cm3 (STP)-cm/cm2-s-cm Hg at 20° for PLL and PG, resp. The ratio of the permeability coeffs. of H and N was considered to be a measure of the degree of compactness between helices of poly(a-amino acid) membranes. Anomalous transient state permeation curves were obsd. for N in PG. The Arrhenius plots of diffusivity for various gases in the polymer with the largest side chain (PLy-Z) show an inflection and are concave to the reciprocal temp. axis. .

Endotoxin contamination in wound dressings made of natural biomaterials

Endotoxin contamination in wound dressings made of natural biomaterials. Nakagawa, Y.; Murai, T.; Hasegawa, Chie; Hirata, M.; Tsuchiya, T.; Yagami, T.; Haishima, Y. (Division of Biological Evaluation, Osaka Branch, National Institute of Health Sciences, Osaka 540-0006, Japan). Journal of Biomedical Materials Research, Part B: Applied Biomaterials, 66B(1), 347-355 (English) 2003 John Wiley & Sons, Inc. CODEN: JBMRGL. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Contamination by endotoxin of 9 kinds of wound dressings made of natural biomaterials (calcium alginate, collagen, chitin, and poly-L-leucine) was examd. with the use of water exts. By applying the Limulus amoebocyte lysate (LAL) test, high concns. of endotoxin were detected in exts. from 3 kinds of products made of calcium alginate. These exts. evoked fever in rabbits and induced the release of a proinflammatory (pyrogenic) cytokine, interleukin-6 (IL-6), from human monocytic cells (MM6-CA8). The effects disappeared when the exts. were treated with endotoxin-removing gel column chromatog. or with an endotoxin antagonist, B464, confirming that the contaminating pyrogen was endotoxin. A noteworthy finding was that one of the endotoxin-contg. 25322-63-8 and 9005-35-0 which are cas registry numbers of substances are two of reagents here. exts. showed very weak IL-6-inducibility in human monocytic cells in contrast to its high pyrogenicity to rabbits. The discrepancy could be explained based on differences between humans and rabbits in sensitivity to the endotoxin, because the ext. showed higher proinflammatory-cytokine (TNF-a)-inducibility in rabbit whole-blood cells (WBCs) than human WBCs. The results suggest that the LAL test is a useful method of detecting endotoxin contamination in wound dressings and the MM6-CA8 assay is a good supplement to the LAL test for evaluating pyrogenicity in humans accurately. .