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Detail of "25332-39-2"

  • CAS Number:
  • 25332-39-2
  • Name:
  • 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-,hydrochloride (1:1)

  • Superlist Name:
  • Trazodone hydrochloride
  • Molecular Structure:
  • Formula:
  • C19H23Cl2N5O
  • Molecular Weight:
  • 408.37
  • Synonyms:
  • s-Triazolo[4,3-a]pyridin-3(2H)-one,2-[3-[4-(m-chlorophenyl)-1-piperazinyl]propyl]-, monohydrochloride (8CI);AF1161;Bimaran;Desyrel;KB 831;Mesyrel;Molipaxin;Pragmazone;Thombran;Tombran;Trazolan;Trittico;Trazodone HCL;
  • EINECS:
  • 246-855-5
  • Boiling Point:
  • 528.5 °C at 760 mmHg
  • Flash Point:
  • 273.4 °C
  • Hazard Symbols:
  • HarmfulXn,IrritantXi
  • Risk Codes:
  • 22-40-36/37/38
  • Safety:
  • 22-36-37/39-26 Details
  • Transport Information:
  • UN 3249

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CAS No.25332-39-2 Trazodone hydrochlorideCompetitive Product

Trazodone Hydrochloride, USP

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[Formula] C19H22CLN5O-HCL [CAS #] 25332-39-2 [Purity] ≥97.0%

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Reference

Effect of trazodone and fluoxetine pretreatment upon fenfluramine- and apomorphine-induced hyperthermia in the rabbit
Effect of trazodone and fluoxetine pretreatment upon fenfluramine- and apomorphine-induced hyperthermia in the rabbit. Quock, Raymond M. (Sch. Pharm., Univ. Pac., Stockton, Calif., USA). Pharmacol. Res. Commun., 9(8), 737-41 (English) 1977. CODEN: PLRCAT. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The influence of the new antidepressant, trazodone-HCl (I) [25332-39-2] upon fenfluramine-HCl [404-82-0] and apomorphine-HCl [314-19-2] induced hyperthermia in the rabbit was studied and compared with that of fluoxetine-HCl [56296-78-7], a known serotonin uptake inhibitor. Both trazodone and fluoxetine reduced the hyperthermic response to fenfluramine and both drug pretreatments also markedly enhanced apomorphine-induced hyperthermia. This supports previous in vitro observations that trazodone might act through selective inhibition of the serotonin uptake process.
Inhibition of the central hypotensive effect of clonidine by trazodone, a novel antidepressant
Inhibition of the central hypotensive effect of clonidine by trazodone, a novel antidepressant. Van Zwieten, P. A. (Lab. Farm., Univ. Amsterdam, Amsterdam, Neth.). Pharmacology, 15(4), 331-6 (English) 1977. CODEN: PHMGBN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Trazodone-HCl (I) [25332-39-2], a nontricyclic drug with antidepressant properties, diminished the central hypotensive response to clonidine-HCl (II) [4205-91-8] in a dose-dependent manner. When both drugs were infused into the left vertebral artery of chloralose-anesthetized cats. I injected i.v. did not reduce the central hypotensive effect of II. The antagonism probably occurs at the level of central .alpha.-adrenoreceptors in the brain stem, where II is the .alpha.-agonist and I the .alpha.-antagonist.
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