Detail of "254-60-4"

Reference

1,8-Naphthyridine deriv

1,8-Naphthyridine deriv. bulged base-recognizing molecule, capable of base-paring and base stacking, for base pair mismatch detection. Nakaya, Kazuhiko; Saito, Akira; Hagiwara, Shinya; Kumasawa, Hiroyuki; Horie, Sota (Japan Science and Technology Corporation, Japan). Jpn. Kokai Tokkyo Koho JP 2003261567 A2 19 Sep 2003, 10 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: ICM: C07D471-04. ICS: C12N015-09; C12Q001-68; G01N033-53; G01N033-566; G01N033-58. APPLICATION: JP 2002-62883 8 Mar 2002. DOCUMENT TYPE: Patent CA Section: 9 (Biochemical Methods) Section cross-reference(s): 3 Bulged base-recognizing mols. having a general formula (I) (A is =C- or =N-; Z = -CH2, or -NH-; R1 = H, C1-15 alkyl group, alkoxy group, or mono or dialkylamino group, where carbon atom may be substituted with O or N atom; R2 = optionally substituted C1-20 alkyl group contg. a functional group capable of forming a covalent bond with the bulged base), and use in detection of base pair mismatch, are disclosed. The mols. also contain a linker for immobilization. A bulged base can be detected by hybridizing a sample DNA with a DNA having normal nucleotide sequence. 1,8-Naphthyridine deriv., 2-(b-(N-epoxy methyl-amino)-propionyl amino)-7-1,8-naphthyridine, in particular, are claimed. A bulged base-recognizing mol. forms specific base-paring hydrogen bonds with the base and is stably incorporated in the double strand by base stacking with the neighboring base pairs. Synthesis of epoxy naphthyridine and use in deletion of bulged base are described.

1,8-Naphthyridines V

1,8-Naphthyridines V. Novel N-substituted 5-amino-N,N-diethyl-9-isopropyl [1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides, as potent anti-inflammatory and/or analgesic agents completely devoid of acute gastrolesivity. Grossi, Giancarlo; Di Braccio, Mario; Roma, Giorgio; Ballabeni, Vigilio; Tognolini, Massimiliano; Barocelli, Elisabetta (Dipartimento di Scienze Farmaceutiche, Universita di Genova, Genoa 16132, Italy). European Journal of Medicinal Chemistry, 40(2), 155-165 (English) 2005 Elsevier Ltd. CODEN: EJMCA5. ISSN: 0223-5234. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Most N,N-disubstituted 5-amino-N,N-diethyl-9-iso-Pr [1,2,4]triazolo[4,3-a] [1,8]naphthyridine-6-carboxamides, e.g., I, and the N-monosubstituted ones were obtained by treating with excess amine the corresponding 5-chloro deriv., which was in turn prepd. by cyclocondensation of the 2,4-dichloro-N,N-diethyl-1,8-naphthyridine-3-carboxamide with isobutyrohydrazide. The synthesized compds., along with two previously described compds., were tested for their anti-inflammatory, analgesic and antipyretic properties, and most compds.Several substances like 327160-25-8 may be metioned in this study. also for their effect on spontaneous mice locomotor activity and their acute gastrolesivity in rats. Several compds. showed potent antiinflammatory and/or analgesic activities, and all the compds. tested proved to be completely lacking in acute gastrolesivity. In many cases the compds. produced hypothermic effect, usually at high doses. On the whole, the N-monosubstituted 5-amino derivs. appeared to be more potent antiinflammatory agents than the corresponding N,N-disubstituted, whereas these latter compds. exhibited higher analgesic activity. .