Reference

1,5-Naphthyridinecarboxylic acid derivatives

1,5-Naphthyridinecarboxylic acid derivatives. Heindl, Joseph; Kessler, Hans Joachim (Schering A.-G., Ger.). Ger. Offen. DE 2607012 25 Aug 1977, 39 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D471-04. APPLICATION: DE 76-2607012 18 Feb 1976. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Naphthyridinecarboxylic acids I (R = MeO, Cl, Br, pyridylthio, Me2N, etc.; R1 = Et, vinyl, allyl; R2 = H, Me, Et) were prepd. for use as bactericides. Thus, 3,5-dibromopyridine was treated succesively with NaOH/MeOH, CuSO4/NH3, and EtOCH2CH(CO2Et)2 to give di-Et (5-methoxy-3-pyridylaminomethylene)malonate, which was cyclized by POCl3 and NaOAc/HOAc to II. Reaction of II with NaH and EtI gave I (R = MeO, R1 = R2 = Et). I are effective against gram-neg. bacteria, e.g., I (R = EtO, R1 = Et, R2 = H) inhibited E. coli at 0. 64436-94-8 is also in the experiment.8 .gamma./mL. .

Derivatives of 1,5-naphthyridine-2-carboxylic acid, their N-oxides, and oxidation-reduction reactions of the di-N-oxide of 1,5-naphthyridine 2-aldehyde

Derivatives of 1,5-naphthyridine-2-carboxylic acid, their N-oxides, and oxidation-reduction reactions of the di-N-oxide of 1,5-naphthyridine 2-aldehyde. Titkova, R. M.; Elina, A.Except for chemicals metioned above, 300-62-9 is also used. S.; Trifonova, E. A.; Gus'kova, T. 300-62-9 is also in the experiment. A. (Vses. Nauchno-Issled. Khim.-Farm. Inst., Moscow, USSR). Khim.-Farm. Zh., 12(6), 81-4 (Russian) 1978. CODEN: KHFZAN. ISSN: 0023-1134. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 1,5-Naphthyridine derivs. I (R = NH2, NHNH2, X = Y = N, NO; R = NH2, X = N, Y = NO; R = NHCHMeCH2Ph, X = Y = NO) were prepd. in 47.4-86.3% yields by esterification of I (R = OH) to give II (R = OEt) which was treated with the corresponding amines. I (R = NH2, NHNH2, NHCHMeCH2Ph, X = Y = NO) exhibited bactericidal and fungicidal activity. ..