Detail of "2552-55-8"

Reference

GLC-mass spectral analysis of fungal metabolites

GLC-mass spectral analysis of fungal metabolites. Repke, David B.; Leslie, Dale Thomas; Kish, Nicholas G. (Los Altos, Calif., USA). J. Pharm. Sci., 67(4), 485-7 (English) 1978. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) Section cross-reference(s): 9, 10 Four metabolites, hispidin (I) [555-55-5], bisnoryangonin (II) [13709-27-8], muscimole (III) [2763-96-4], and ibotenic acid (IV) [2552-55-8], from potentially psychoactive mushrooms, were analyzed by gas-liq. chromatog.-mass spectrometry as their trimethylsilyl derivs. This method was applied to I and II in Gymnopilus punctifolius (Peck) Singer and to III and IV in Amanita pantherina (Fr.) Secr.

Characterization of striatal ibotenate lesions and of 6-hydroxydopamine-induced nigral lesions by morphometric and densitometric approaches

Characterization of striatal ibotenate lesions and of 6-hydroxydopamine-induced nigral lesions by morphometric and densitometric approaches. Agnati, L. F.; Fuxe, K.; Calza, L.; Benfanati, F.; Battistini, N.; Zini, I.; Fabbri, L.; Goldstein, M. (Dep. Hum. Physiol., Univ. Modena, Modena 41100, Italy). Wenner-Gren Cent. Int. Symp. Ser., Volume Date 1982, 39(Excitotoxins), 239-50 (English) 1984. CODEN: WGCSAA. ISSN: 0083-7989. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The effects of the neurotoxins ibotenic acid (I) [2552-55-8] and 6-hydroxydopamine (II) [1199-18-4] on the nigrostriatal dopamine (DA) system were evaluated at the striatal level in the rat by means of morphometrical and densitometrical anal. Twenty two days following a I-induced lesion a marked increase was obsd. in the contents of tyrosine hydroxylase immunoreactivity in the striatal DA nerve terminals. Combined lesions of II-induced nigral lesions and contralateral striatal I lesions revealed a marked unbalance of 3H-spiperone binding between the 2 striata of these animals. Rotational behavior induced by apomorphine was highest in animals with this type of combined lesions. Synaptic plasticity in response to neurotoxin-induced lesions at the pre- and postsynaptic levels can be excellently studied by a morphometric and densitometric anal. of transmitter-identified neurons in the lesioned area. The usefulness of I as a neurotoxin, producing axon-sparing lesions in discrete areas of the mammalian brain without introducing distant lesions, is further documented.