Detail of "257-07-8"

CAS Number:
257-07-8
Name:
Dibenz[b,f][1,4]oxazepine
Molecular Structure:
Formula:
C13H9 N O
Molecular Weight:
195.23
Synonyms:
CR; CR(lacrimator); NSC 293779
Density:
1.16g/cm³
Boiling Point:
329.3°Cat760mmHg
Flash Point:
125°C
Safety:
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion and inhalation. Experimental teratogenic and reproductive effects. A human skin and eye irritant. Questionable carcinogen with experimental carcinogenic and tumorigenic data. When heated to decomposition it emits toxic fumes of NO_x. Details

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Acute effect of dibenz[b,f][1,4]oxazepine aerosol upon the lung function of healthy young men: Acute effect of dibenz[b,f][1,4]oxazepine aerosol upon the lung function of healthy young men. Ashton, I.; Cotes, J. E.; Holland, P.; Johnson, G. R.; Legg, S. J.; Saunders, M. J.; White, R. G. (MRC Pneumoconiosis Unit., Llandough Hosp., Penarth, Wales). J. Physiol. (London), 275 85P (English) 1978. CODEN: JPHYA7. ISSN: 0022-3751. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Exposure to dibenz[b,f][1,4]oxazepine [257-07-8] (aerosol, particle size 1-2 m, for 1 h, mean concn. 0.25 mg/m3) diminished the peak expiratory flow rate (7% after 20 min) and increased the transfer factor (T1') and the KCO (T1'/alveolar vol.) (~5% after 1 h). The vol. of gas inhaled during the measurement was decreased by 3%, but the alveolar vol. was unchanged. The resting cardiac frequency increased transiently after the start of the exposure and the V-iso v on av. increased by 15%. The aerosol either stimulates pulmonary irritant receptors, causing bronchoconstriction, or induces acute discomfort which augments sympathetic tone, and hence probably increases pulmonary blood vol., and also mitigates the bronchoconstriction.

Toxicology of CR: Toxicology of CR. Bandman, A. L.; Savateev, N. V. (USSR). Voen.-Med. Zh., (3), 84-6 (Russian) 1977. CODEN: VMEZA4. DOCUMENT TYPE: Journal; General Review CA Section: 4 (Toxicology) A review with 17 refs. on toxic and irritant activity of dibenz(b,f)-1,4-oxazepine (I) [257-07-8].