Reference

Effect of molsidomine on coronary artery diameter, coronary resistance and venous system in conscious dogs

Effect of molsidomine on coronary artery diameter, coronary resistance and venous system in conscious dogs. Bassenge, E.; Holtz, J.; Kolin, A. (Univ. Freiburg, Freiburg 7800, Fed. Rep. Ger.). Molsidomin: Neue Aspekte Ther. Ischaemischen Herzerkr., Int. Symp., 3rd, 11-25. Edited by: Bassenge, Eberhard: Schmutzler, Horst. Urban & Schwarzenberg: Munich, Fed. Rep. Ger. (German) 1982. CODEN: 51ZXAS. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Molsidomine (I) [25717-80-0] i.v. bolus injection at 0.1 mg/kg into conscious, chronically instrumented dogs at rest decreased left-ventricular end-diastolic pressure, contractile vol., and mean arterial pressure, but did not change heart rate, dp/dt, and peripheral resistance. Venous dilation was obsd. 4 min after I administration and reached a max of 22% at 20 min postadministration. The effective compliance of the total vascular system was increased 62% by I. Epicardial coronary artery dilation was obsd. 4 min after I administration and reached a max. of 12% at 20 min postadministration. With i.v. infusion of the I metabolite SIN-1 [33876-97-0], the threshold dose causing epicardial coronary dilation was 0.01-0.03 mg/kg/min, and that causing a decrease in arterial pressure was 3.3 mg/kg/min.

Effect of molsidomine on the acid-base balance in arterial blood and lactate metabolism of cardiac muscle under frequent stress

Effect of molsidomine on the acid-base balance in arterial blood and lactate metabolism of cardiac muscle under frequent stress. Saborowski, F.; Griebenow, R. (Univ. Koeln., Cologne 5000/91, Fed. Rep. Ger.). Molsidomin: Neue Aspekte Ther. Ischaemischen Herzerkr., Int. Symp., 3rd, 128-38. Edited by: Bassenge, Eberhard; Schmutzler, Horst. Urban & Schwarzenberg: Munich, Fed. Rep. Ger. (German) 1982. CODEN: 51ZXAS. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacology) Molsidomine (I) [25717-80-0] administration to cardiac patients did not alter the acid-base balance, electrolyte (K+, Na+) concns., or free fatty acid levels of arterial blood when compared to that obsd. in untreated control. I, however, increased the mean lacate [50-21-5] concn. from 6.9 to 9.2 mg/dL even though conditions of hyperventilation and hypoxemia were not evident. Under conditions of cardiac stress, (90-110 beats/min), I administration decreased the mean lactate consumption when compared to that obsd. in untreated controls; this effect was assocd. with a reduced O consumption by the stressed heart muscle.