Detail of "2577-40-4"

Reference

Photocontrol of organic synthesis using immobilized enzyme

Photocontrol of organic synthesis using immobilized enzyme. Karube, Isao; Matsuoka, Hideaki; Yamazaki, Motoo; Suzuki, Shuichi (Res. Lab. Resour. Util., Tokyo Inst.Some commonly used reagents like 86653-17-0 and 55779-26-5 are used in this experiment. Technol., Yokohama 227, Japan). Nippon Kagaku Kaishi, (9), 1329-35 (Japanese) 1983. CODEN: NKAKB8. ISSN: 0369-4577. DOCUMENT TYPE: Journal CA Section: 16 (Fermentation and Bioindustrial Chemistry) Section cross-reference(s): 28, 34 Peptide synthesis was accomplished with a protease immobilized in the presence of a photochromic compd., 3',3'-dimethyl-8-methoxy-6-nitrospiro[2H-1-benzopyran-2,2'-indoline]- 1'-propionic acid (I) [86653-17-0], under visible light. a-Chymotrypsin [9004-07-3] was immobilized with I in a collagen membrane. The complex showed reverse photochromism and formed the protected deriv. of L-phenylalanyl-L-phenylalanine [2577-40-4] from N-acetylphenylalanine and L-phenylalanine Et ester. The yield was 6% in 35 h under 30,000 lx illumination. .

The effects of salicylate on the rectal absorption of phenylalanine and some peptides, and the effects of these peptides on the rectal absorption of cefoxitin and cefmetazole

The effects of salicylate on the rectal absorption of phenylalanine and some peptides, and the effects of these peptides on the rectal absorption of cefoxitin and cefmetazole. Nishihata, Toshiaki; Lee, Chia Shun; Yamamoto, Midori; Rytting, J. Howard; Higuchi, Takeru (Dep. Pharm. Chem., Univ. Kansas, Lawrence, KS 66045, USA). J. Pharm. Sci., 73(9), 1326-8 (English) 1984. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The disappearance of phenylalanine [63-91-2] and phenylalanylglycine [721-90-4] from a perfusate circulated across rat rectal tissue was enhanced significantly in the presence of salicylate [69-72-7] or 5-methoxysalicylate [2612-02-4] at pH 4.5, 7.4, and 8.5. The disappearance of di- [2577-40-4], tri- [2578-81-6], and tetraphenylalanine [2667-02-9] from a perfusate at pH 7.4, although facilitated by the presence of salicylate and 5-methoxysalicylate, was also fairly substantial when no adjuvant was present. These peptide analogs of phenylalanine also enhanced the rectal absorption of cefoxitin [35607-66-0] and cefmetazole [56796-20-4], 2 highly water sol. antibiotics. Phenylalanine and phenylalanylglycine, both poorly absorbed across the rectal membrane when administered alone, did not enhance the rectal absorption of either antibiotic.