Reference

Effect of phenoxy acids on rat liver regeneration

Effect of phenoxy acids on rat liver regeneration. Gershbein, Leon L. (Northwest Inst. Med. Res., Chicago, IL 60634, USA). Res. Commun. Chem. Pathol. Pharmacol., 43(2), 325-34 (English) 1984. CODEN: RCOCB8. ISSN: 0034-5164. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 5 Phenoxy-acids incorporated in a basal ration on a wt. basis, were fed to male rats from which two-thirds of the liver had been removed and the extent of regeneration or the liver increment was ascertained over a period of 10 days postoperative (p.o.). Stimulatory responses occurred with the hypolipidemic drug, ethyl clofibrate [637-07-0], at levels of 0.25% and higher or by gavage over the 1st 8 days p.o. at an overall dosage of 1275 mg/kg, with 2-(p-chlorophenoxy)propionic acid [3307-39-9] (0.50, 1.0%), the corresponding o-chloro-acids (0.20 and 0.50%, resp.) and several other compds. with branching of the acid side chain. The latter included phenoxyisobutyric acid [943-45-3] (0.50%), 2-phenoxypropionic acid [940-31-8] (1.0%), 2-phenoxybutyric acid [13794-14-4] (1.0%), the phenoxydimethylpentanoic acid, gemfibrozil [25812-30-0] (0.40%), the herbicide, 2-(2,4,5-trichlorophenoxy)propionic acid [93-72-1] (0.10%) and, as screened on a few males, possibly halofenate [26718-25-2] (0.20%). The liver increments were in the control range for compds. contg. straight-chain acid substituents, such as 4-(p-chlorophenoxy)butyric acid [3547-07-7] (0.35%), 3-phenoxypropionic acid [7170-38-9] (0.75%), 3-(p-chlorophenoxy)-1,2-propanediol [104-29-0] (0.50%) and phenoxyacetic acid derivs., including p-chloroacetic acid [122-88-3] and the herbicides 2,4-dichlorophenoxy- [94-75-7], 2-methyl-4-chlorophenoxy [94-74-6] and 2,4,5-trichlorophenoxyacetic acid [93-76-5] at levels of up to about 0.50%. When the phenoxyacetic acids caused any effects, these were inhibitory of the regeneration process. The response of the female rat to clofibrate either by diet or gavage was rather poor or equivocal but was more definite with 2-(2,4,5-trichlorophenoxy)propionic acid (0.10%).In this experiment, several chemicals are used like 940-31-8 and 26718-25-2 However, intact females were more consistent in eliciting wet and dry liver enlargement with clofibrate (0.25%), as noted earlier by others, and with gemfibrizol (0.040%) and trichlorophenoxypropionic acid (0.10%), but not with 2,4,5-trichlorophenoxyacetic acid at 0.10%. .

Effect of gemfibrozil in vitro on fat-mobilizing lipolysis in human adipose tissue

Effect of gemfibrozil in vitro on fat-mobilizing lipolysis in human adipose tissue. Carlson, L. A. (King Gustaf V Res. Inst., Karolinska Inst., Stockholm, Swed.). Proc. R. Soc. Med., 69(Suppl. 2), 101-3 (English) 1976. CODEN: PRSMA4. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In incubated rat fat gemfibrozil (I) [25812-30-0] (1 mg/mL) and clofibrate (II) [637-07-0] (1 mg/mL) inhibited basal as well as noradrenaline-stimulated fat-mobilizing lipolysis, detd. by following glycerol release into the incubation medium. With human adipose tissue no effect on basal lipolysis was obsd. using I or II. However, both I and II inhibited lipolysis stimulated with noradrenaline or with isoprenaline; neither inhibited theophylline-stimulated lipolysis.