Reference

Cardenolide analogs

Cardenolide analogs. 7. Synthesis and biological activity of some new steroidal guanylhydrazones. Gelbart, Alex; Thomas, Richard (Dep. Pharm., Univ. Sydney, Sydney, Aust.). J. Med. Chem., 21(3), 284-8 (English) 1978. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 32 Four nondigitalis-like steroid guanylhydrazones were prepd. by the condensation of aminoguanidine bicarbonate [2582-30-1] with the appropriate 17b-formyl steroids, which were generated by periodate fission of the corresponding 20,21-diols. All the compds. inhibited Na-K-activated ATPase [9000-83-3] to about the same extent, but also inhibited ouabain-insensitive Mg-activated ATPase. Previously prepd. I [42516-40-5], a digitalis-like guanylhydrazone, was a specific inhibitor of Na-K-activated ATPase and also gave a pos. inotropic effect on the isolated guinea pig atrium. The mechanism of action and structure-activity relations are discussed.

Removal of free formaldehyde from amino resins for coating compositions

Removal of free formaldehyde from amino resins for coating compositions. Kamachi, Tetsuya (Nippon Carbide Industries Co., Inc., Japan). Japan. Kokai JP 52095745 11 Aug 1977 Showa, 4 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C09D003-50. APPLICATION: JP 76-11284 6 Feb 1976. DOCUMENT TYPE: Patent CA Section: 42 (Coatings, Inks, and Related Products) Amino resins were treated with aminoguanidine bicarbonate (I) [2582-30-1] or guanylurea phosphate [17675-60-4] to remove free HCHO [50-00-0]. Thus, a mixt. of 88.2 g melamine, 217.2 g 87% paraformaldehyde, 362.9 g MeOH, and NaOH at pH 9-10 was heated at reflux, adjusted to pH 2 with HCl, heated at 30-50°, neutralized, distd. to remove MeOH, mixed with 3.8 g I and 60 g BuOH, heated at 60°, and filtered to prep. a soln. of a polymer having 0.01% free HCHO.