Detail of "25827-76-3"

CAS Number:
25827-76-3
Name:
Pentanoic acid,5-[(3-amino-2,4,6-triiodophenyl)methylamino]-5-oxo-
Molecular Structure:
Formula:
C12H13 I3 N2 O3
Molecular Weight:
0
Synonyms:
Glutaranilicacid, 3'-amino-2',4',6'-triiodo-N-methyl- (8CI); Falignost; Iomeglamic acid;Iomeglamis acid
Density:
2.42g/cm³
Boiling Point:
665.1°Cat760mmHg
Flash Point:
356.1°C

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Improvement of the dissolution behavior of problem drugs: Improvement of the dissolution behavior of problem drugs. Part 13. Iomeglamic acid-methyl cellulose-PEG 6000 coprecipitates. Fahr, F.; Kala, H.; Hueckel, T. (Sekt. Pharm., Martin-Luther-Univ. Halle-Wittenberg, Halle/Saale DDR-4020, Ger. Dem. Rep.). Pharmazie, 41(9), 668-9 (German) 1986. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Coppts. of iomeglamic acid (I) [25827-76-3]-Me cellulose [9004-67-5] and PEG 6000 [25322-68-3] were prepd. by letting Me cellulose swell in CHCl3-MeOH (7:3) for 45-60 min, adding PEG and I. The residue obtained after solvent evapn. was dried and powd. to a predetd. particle size. The dissoln. rate was dependent on the particle size of the coppt. 9004-67-5 and 25322-68-3 which are cas registry numbers of chemicals are mentioned. particles, the coppt. with a particle size of <500 mm showing a better dissoln. than the coppt. with the size of >500 mm. Only the coppts. with particle size <500 mm gave supersatd. solns. during dissoln. testing. .

Improvement of the dissolution behavior of problem drugs: Improvement of the dissolution behavior of problem drugs. 2. Dissolution behavior of melting-solidification products of iomeglamic acid and succinic acid. Fahr, F.; Kala, H.; Scharrenweber, F. (Sekt. Pharm., Martin-Luther-Univ. Halle-Wittenberg, Halle DDR-4020, Ger. Dem. Rep.). Pharmazie, 40(1), 60-1 (German) 1985. CODEN: PHARAT. ISSN: 0031-7144. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The use of succinic acid (I) [110-15-6] as a carrier improved the dissoln. behavior of iomeglamic acid (II) [25827-76-3] as compared to the pure II or II subjected to melting and solidification. This effect was directly proportional to the portion of the excipient in the melted solidified product. During storage of a 2% solid dispersion the dissoln. decreased somewhat. In a 20% dispersion, this could not be detd. The dissoln. was better with melted solidified I-II than with the melted-solidified II. The melted-solidified II showed a complete amorphous structure. Aging in 2% drug-contg. product indicates that II must be imbedded in a particular form in I.