Detail of "258516-87-9"

Reference

Methods of dosing propofol prodrugs for inducing mild to moderate levels of sedation

All Rights Reserved. Methods of dosing propofol prodrugs for inducing mild to moderate levels of sedation. Gibiansky, Ekaterina; Gibiansky, Leonid (Mgi Gp, Inc., USA). PCT Int. Appl. WO 2007008869 A1 18 Jan 2007, 41pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-US26840 11 Jul 2006. PRIORITY: US 2005-698404P 12 Jul 2005.Several substances with their cas registry numbers 258516-89-1 and 258516-87-9 may be metioned in this study. DOCUMENT TYPE: Patent CA Section: 1 (Pharmacology) Section cross-reference(s): 63 A dosage of a propofol prodrug needed for inducing mild to moderate sedation levels in a patient is calcd. based on a patient's lean body mass. It has been discovered that dosages based on gross body mass may result in overdosing, particularly for obese patients. In another aspect, a dosage suitable for inducing mild to moderate sedation levels in a patient who is at least 60 years of age is detd. A wt.-appropriate dosage for the patient is detd. and then adjusted by an age-based factor. For example, the dosage needed to produce a sedated state or other effect in a patient who is 60 years of age or older may be about 0.6 - 0.8 times the dosage needed to produce a corresponding effect in a younger patient of the same wt. .