Reference

Terminating pregnancy

Terminating pregnancy. Grunwell, Joyce F.; Johnston, John O. (Richardson-Merrell Inc., USA). U.S. US 4073899 14 Feb 1978, 7 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-565. NCL: 424238000. APPLICATION: US 74-506255 16 Sep 1974. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 32 7a-Methylestr-5-ene-3b,17b-diol (I) [3219-68-9] and its acetate [2548-25-6] are useful as contragestative agents for the termination of pregnancy and as antiimplantation agents. These compds. also have low estrogenicity and are useful for reducing fertility in animals. Capsule-shaped troches were prepd. with I 15, pectin 370, gelatin 370, and Na CM-cellulose 370 g. S.c. administration of I to mated female hamsters, during days 8 through 12 of pregnancy, demonstrated a high degree of antiimplantation activity. I was prepd. by LiAlH4 redn. of 17b-hydroxy-7a-methylestr-5-en-3-one acetate (II) [54793-00-9]. II was prepd. by alkylation of 17b-hydroxyestra-4,6-dien-3-one acetate [2590-41-2] with LiCuMe2.